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The paper concerns the study of the Rice statistical distribution’s peculiarities which cause the possibility of its efficient application in solving the tasks of high precision phase measuring in optics. The strict mathematical proof of the Rician distribution’s stable character is provided in the example of the differential signal consideration, namely: it has been proved that the sum or the difference of two Rician signals also obey the Rice distribution. Besides, the formulas have been obtained for the parameters of the resulting summand or differential signal’s Rice distribution. Based upon the proved stable character of the Rice distribution a new original technique of the high precision measuring of the two quasi-harmonic signals’ phase shift has been elaborated in the paper. This technique is grounded in the statistical analysis of the measured sampled data for the amplitudes of the both signals and for the amplitude of the third signal which is equal to the difference of the two signals to be compared in phase. The sought-for phase shift of two quasi-harmonic signals is being calculated from the geometrical considerations as an angle of a triangle which sides are equal to the three indicated signals’ amplitude values having been reconstructed against the noise background. Thereby, the proposed technique of measuring the phase shift using the differential signal analysis, is based upon the amplitude measurements only, what significantly decreases the demands to the equipment and simplifies the technique implementation in practice. The paper provides both the strict mathematical substantiation of a new phase shift measuring technique and the results of its numerical testing. The elaborated method of high precision phase measurements may be efficiently applied for solving a wide circle of tasks in various areas of science and technology, in particular — at distance measuring, in communication systems, in navigation, etc.

The simplest and most desirable method of traffic signal control is precalculated regulation, when the parameters of the traffic light object operation are calculated in advance and activated in accordance to a schedule. This work proposes a method of forming a signal plan that allows one to calculate the control programs and set the period of their activity. Preparation of initial data for the calculation includes the formation of a time series of daily traffic intensity with an interval of 15 minutes. When carrying out field studies, it is possible that part of the traffic intensity measurements is missing. To fill up the missing traffic intensity measurements, the spline interpolation method is used. The next step of the method is to calculate the daily set of signal plans. The work presents the interdependencies, which allow one to calculate the optimal durations of the control cycle and the permitting phase movement and to set the period of their activity. The present movement control systems have a limit on the number of control programs. To reduce the signal plans' number and to determine their activity period, the clusterization using the $k$-means method in the transport phase space is introduced In the new daily signal plan, the duration of the phases is determined by the coordinates of the received cluster centers, and the activity periods are set by the elements included in the cluster. Testing on a numerical illustration showed that, when the number of clusters is 10, the deviation of the optimal phase duration from the cluster centers does not exceed 2 seconds. To evaluate the effectiveness of the developed methodology, a real intersection with traffic light regulation was considered as an example. Based on field studies of traffic patterns and traffic demand, a microscopic model for the SUMO (Simulation of Urban Mobility) program was developed. The efficiency assessment is based on the transport losses estimated by the time spent on movement. Simulation modeling of the multiprogram control of traffic lights showed a 20% reduction in the delay time at the traffic light object in comparison with the single-program control. The proposed method allows automation of the process of calculating daily signal plans and setting the time of their activity.

The paper presents results of experimental, computational and analytical study of the effect of nonequilibrium chemical activation of air-fuel mixture on effectiveness of Diesel process. The generation of a high-voltage multi-streamer discharge in combustion chamber at the compression phase is considered as the method of the activation. The description of electrical discharge system, results of measurement and visualization are presented. The plasma-chemical kinetics of nonequilibrium ignition is analyzed to establish a passway for a proper reduction of chemical kinetics scheme. The results of numerical simulation of gas dynamic processes at presence of plasma-assisted combustion in a geometrical configuration close to the experimental one are described.

The article presents the intermediate results of the development of a control system for a remotely piloted agricultural aircraft (RPAA). The concept of using an automated complex for performing aerochemical work (ACW) designed for processing fields, water areas, forests with the purpose of protection from pests of plants, fertilization is developed. The basic component of the complex is a manned agricultural aircraft MV-500 developed by LLC “Firm “MVEN” (Kazan). The use of the aircraft in unmanned mode will provide an increase in the productivity of the aircraft, will increase the payload.

The article defines the composition of the complex for automation of ACW: aircraft, ground control center, onboard equipment for automated control of the aircraft and the formation of a map of the heights of the section being processed, and the satellite precise positioning system necessary to automate the control of the aircraft. The aircraft is equipped with an automated control system that provides remote control of take-off and landing and automatic control of the flight trajectory at extremely low altitude when performing ACW and performing spatial turns at the boundaries of the treated areas. It is proposed to take off, landing, dropping an aircraft into the ACW exercise area by means of a pilot operator from a ground control station. The ground control point should provide reception and display on the operator's screen of flight information and several types from the aircraft. The operator can control alternately several aircraft during these phases of flight with the help of ground control authorities. In the future, it is planned to automate these stages of flight, leaving behind the pilot-operator control functions and remote control capabilities in special cases. For the navigation of the aircraft, when performing ACW on board, RTK (Real Time Kinematic) equipment is installed, providing a measurement with centimeter accuracy of coordinates and aircraft heights relative to the base station installed in the ground control station. Before the implementation of ACW, a three-dimensional digital map of the processed area is built by adding existing cadastral maps with measurements of the elevations of the section carried out with the help of on-board radio and optical altimeters of the same aircraft.

To date, the following system components have been manufactured and tested: a remotely controlled model of the MV-500 aircraft at a scale of 1:5, a satellite positioning system; system for obtaining images and telemetry information from the board model; autopilot; methods of obtaining three-dimensional digital maps of sections and planning flight trajectories for ACW.

Mathematical models of gas dynamics and its computational industry, in our opinion, are far from perfect. We will look at this problem from the point of view of a clear probabilistic micro-model of a gas from hard spheres, relying on both the theory of random processes and the classical kinetic theory in terms of densities of distribution functions in phase space, namely, we will first construct a system of nonlinear stochastic differential equations (SDE), and then a generalized random and nonrandom integro-differential Boltzmann equation taking into account correlations and fluctuations. The key feature of the initial model is the random nature of the intensity of the jump measure and its dependence on the process itself.

Briefly recall the transition to increasingly coarse meso-macro approximations in accordance with a decrease in the dimensionalization parameter, the Knudsen number. We obtain stochastic and non-random equations, first in phase space (meso-model in terms of the Wiener — measure SDE and the Kolmogorov – Fokker – Planck equations), and then — in coordinate space (macro-equations that differ from the Navier – Stokes system of equations and quasi-gas dynamics systems). The main difference of this derivation is a more accurate averaging by velocity due to the analytical solution of stochastic differential equations with respect to the Wiener measure, in the form of which an intermediate meso-model in phase space is presented. This approach differs significantly from the traditional one, which uses not the random process itself, but its distribution function. The emphasis is placed on the transparency of assumptions during the transition from one level of detail to another, and not on numerical experiments, which contain additional approximation errors.

The theoretical power of the microscopic representation of macroscopic phenomena is also important as an ideological support for particle methods alternative to difference and finite element methods.

The paper proposes a mathematical model for the therapy of glioma, taking into account the blood-brain barrier, radiotherapy and antibody therapy. The parameters were estimated from experimental data and the evaluation of the effect of parameter values on the effectiveness of treatment and the prognosis of the disease were obtained. The possible variants of sequential use of radiotherapy and the effect of antibodies have been explored. The combined use of radiotherapy with intravenous administration of $mab$ $Cx43$ leads to a potentiation of the therapeutic effect in glioma.

Radiotherapy must precede chemotherapy, as radio exposure reduces the barrier function of endothelial cells. Endothelial cells of the brain vessels fit tightly to each other. Between their walls are formed so-called tight contacts, whose role in the provision of BBB is that they prevent the penetration into the brain tissue of various undesirable substances from the bloodstream. Dense contacts between endothelial cells block the intercellular passive transport.

The mathematical model consists of a continuous part and a discrete one. Experimental data on the volume of glioma show the following interesting dynamics: after cessation of radio exposure, tumor growth does not resume immediately, but there is some time interval during which glioma does not grow. Glioma cells are divided into two groups. The first group is living cells that divide as fast as possible. The second group is cells affected by radiation. As a measure of the health of the blood-brain barrier system, the ratios of the number of BBB cells at the current moment to the number of cells at rest, that is, on average healthy state, are chosen.

The continuous part of the model includes a description of the division of both types of glioma cells, the recovery of BBB cells, and the dynamics of the drug. Reducing the number of well-functioning BBB cells facilitates the penetration of the drug to brain cells, that is, enhances the action of the drug. At the same time, the rate of division of glioma cells does not increase, since it is limited not by the deficiency of nutrients available to cells, but by the internal mechanisms of the cell. The discrete part of the mathematical model includes the operator of radio interaction, which is applied to the indicator of BBB and to glial cells.

Within the framework of the mathematical model of treatment of a cancer tumor (glioma), the problem of optimal control with phase constraints is solved. The patient’s condition is described by two variables: the volume of the tumor and the condition of the BBB. The phase constraints delineate a certain area in the space of these indicators, which we call the survival area. Our task is to find such treatment strategies that minimize the time of treatment, maximize the patient’s rest time, and at the same time allow state indicators not to exceed the permitted limits. Since the task of survival is to maximize the patient’s lifespan, it is precisely such treatment strategies that return the indicators to their original position (and we see periodic trajectories on the graphs). Periodic trajectories indicate that the deadly disease is translated into a chronic one.

Metal hydrides are an interesting class of chemical compounds that can reversibly bind a large amount of hydrogen and are, therefore, of interest for energy applications. Understanding the factors affecting the kinetics of hydride formation and decomposition is especially important. Features of the material, experimental setup and conditions affect the mathematical description of the processes, which can undergo significant changes during the processing of experimental data. The article proposes a general approach to numerical modeling of the formation and decomposition of metal hydrides and solving inverse problems of estimating material parameters from measurement data. The models are divided into two classes: diffusive ones, that take into account the gradient of hydrogen concentration in the metal lattice, and models with fast diffusion. The former are more complex and take the form of non-classical boundary value problems of parabolic type. A rather general approach to the grid solution of such problems is described. The second ones are solved relatively simply, but can change greatly when model assumptions change. Our experience in processing experimental data shows that a flexible software tool is needed; a tool that allows, on the one hand, building models from standard blocks, freely changing them if necessary, and, on the other hand, avoiding the implementation of routine algorithms. It also should be adapted for high-performance systems of different paradigms. These conditions are satisfied by the HIMICOS library presented in the paper, which has been tested on a large number of experimental data. It allows simulating the kinetics of formation and decomposition of metal hydrides, as well as related tasks, at three levels of abstraction. At the low level, the user defines the interface procedures, such as calculating the time layer based on the previous layer or the entire history, calculating the observed value and the independent variable from the task variables, comparing the curve with the reference. Special algorithms can be used for solving quite general parabolic-type boundary value problems with free boundaries and with various quasilinear (i.e., linear with respect to the derivative only) boundary conditions, as well as calculating the distance between the curves in different metric spaces and with different normalization. This is the middle level of abstraction. At the high level, it is enough to choose a ready tested model for a particular material and modify it in relation to the experimental conditions.

The results of determination of the risk of cardiovascular failure of young athletes and adolescents in stressful physical activity have been demonstrated. The method of screening diagnostics of the risk of developing heart failure has been described. The results of contactless measurement of the form of the pulse wave of the radial artery using semiconductor laser autodyne have been presented. In the measurements used laser diode type RLD-650 specifications: output power of 5 mW, emission wavelength 654 nm. The problem was solved by the reduced form of the reflector movement, which acts as the surface of the skin of the human artery, tested method of assessing the risk of cardiovascular disease during exercise and the analysis of the results of its application to assess the risk of cardiovascular failure reactions of young athletes. As analyzed parameters were selected the following indicators: the steepness of the rise in the systolic portion of the fast and slow phase, the rate of change in the pulse wave catacrota variability of cardio intervals as determined by the time intervals between the peaks of the pulse wave. It analyzed pulse wave form on its first and second derivative with respect to time. The zeros of the first derivative of the pulse wave allow to set aside time in systolic rise. A minimum of the second derivative corresponds to the end of the phase and the beginning of the slow pressure build-up in the systole. Using the first and second derivative of the pulse wave made it possible to separately analyze the pulse wave form phase of rapid and slow pressure increase phase during systolic expansion. It has been established that the presence of anomalies in the form of the pulse wave in combination with vagotonic nervous regulation of the cardiovascular system of a patient is a sign of danger collapse of circulation during physical exercise.

Heart rate (HR) is the most affordable indicator for measuring. In order to control the individual response to physical exercises of different load types heart rate is measured when the athletes perform different types of muscular work (strength machines, various types of training and competitive exercises). The magnitude of heart rate and its dynamics during muscular work and recovery can be objectively judged on the functional status of the cardiovascular system of an athlete, the level of its individual physical performance, as well as an adaptive response to a particular exercise. However, the heart rate is not an independent determinant of the physical condition of an athlete. HR size is formed by the interaction of the basic physiological mechanisms underlying cardiac hemodynamic ejection mode. Heart rate depends on one hand, on contractility of the heart, the venous return, the volumes of the atria and ventricles of the heart and from vascular heart load, the main components of which are elastic and peripheral resistance of the arterial system on the other hand. The values of arterial system vascular resistances depend on the power of muscular work and its duration. HR sensitivity to changes in heart load and vascular contraction was determined in athletes by pair regression analysis simultaneously recorded heart rate data, and peripheral $(R)$ and elastic $(E_a)$ resistance (heart vascular load), and the power $(W)$ of heartbeats (cardiac contractility). The coefficients of sensitivity and pair correlation between heart rate indicators and vascular load and contractility of left ventricle of the heart were determined in athletes at rest and during the muscular work on the cycle ergometer. It is shown that increase in both ergometer power load and heart rate is accompanied by the increase of correlation coefficients and coefficients of the heart rate sensitivity to $R$, $E_a$ and $W$.