<p>Dynamics analysis of coupled synthetic genetic repressilators</p>

Potapov I.S.; Volkov E.I.

Issue 4, 2010 Vol. 2

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Dynamics analysis of coupled synthetic genetic repressilators

Potapov I.S., Volkov E.I.

pdf (710K) / List of references

We have investigated dynamics of synthetic genetic oscillators — repressilators — coupled through autoinducer diffusion. The model of the system with phase-repulsive coupling structure is under consideration. We have examined emergence of periodic regimes, stable inhomogeneous steady states depending on the main systems’ parameters: coupling strength and maximal transcription rate. It has been shown that autoinducer production module added to the isolated repressilator cause the limit cycle to disappear through infinite period bifurcation for sufficiently large transcription rate. We have found hysteresis of limit cycle and stable steady state the size of which is determined by ratio between mRNA and protein lifetimes. Two coupled oscillators system demonstrates stable anti-phase oscillations which can become a chaotic regime through invariant torus emergence or via Feigenbaum scenario.

Keywords: oscillator, genetic circuit, autoinducer, bifurcation analysis

Citation in English: Potapov I.S., Volkov E.I. Dynamics analysis of coupled synthetic genetic repressilators // Computer Research and Modeling, 2010, vol. 2, no. 4, pp. 403-418

DOI: 10.20537/2076-7633-2010-2-4-403-418

URL: http://crm-en.ics.org.ru/journal/article/1751/

Computer Research and Modeling - 2010 - Issue 4

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