Platelet transport and adhesion in shear blood flow: the role of erythrocytes

Tokarev A.A., Butylin A.A., Ataullakhanov F.I.
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Hemostatic system serves the organism for urgent repairs of damaged blood vessel walls. Its main components – platelets, the smallest blood cells, – are constantly contained in blood and quickly adhere to the site of injury. Platelet migration across blood flow and their hit with the wall are governed by blood flow conditions and, in particular, by the physical presence of other blood cells – erythrocytes. In this review we consider the main regularities of this influence, available mathematical models of platelet migration across blood flow and adhesion based on "convection-diffusion" PDEs, and discuss recent advances in this field. Understanding of the mechanisms of these processes is necessary for building of adequate mathematical models of hemostatic system functioning in blood flow in normal and pathological conditions.

Keywords: platelets, blood flow, shear flow, segregation of suspensions, cell adhesion, convection-diffusion partial differential equations
Citation in English: Tokarev A.A., Butylin A.A., Ataullakhanov F.I. Platelet transport and adhesion in shear blood flow: the role of erythrocytes // Computer Research and Modeling, 2012, vol. 4, no. 1, pp. 185-200
Citation in English: Tokarev A.A., Butylin A.A., Ataullakhanov F.I. Platelet transport and adhesion in shear blood flow: the role of erythrocytes // Computer Research and Modeling, 2012, vol. 4, no. 1, pp. 185-200
DOI: 10.20537/2076-7633-2012-4-1-185-200
URL: http://crm-en.ics.org.ru/journal/article/1866/
Creative Commons License This work is licensed under a Creative Commons Attribution-NoDerivs 3.0 Unported License.
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