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The problem of optimal control of traffic flow in an urban road network is considered. The control is carried out by varying the duration of the working phases of traffic lights at controlled intersections. A description of the control system developed is given. The control system enables the use of three types of control: open-loop, feedback and manual. In feedback control, road infrastructure detectors, video cameras, inductive loop and radar detectors are used to determine the quantitative characteristics of current traffic flow state. The quantitative characteristics of the traffic flows are fed into a mathematical model of the traffic flow, implemented in the computer environment of an automatic traffic flow control system, in order to determine the moments for switching the working phases of the traffic lights. The model is a system of finite-difference recurrent equations and describes the change in traffic flow on each road section at each time step, based on retrived data on traffic flow characteristics in the network, capacity of maneuvers and flow distribution through alternative maneuvers at intersections. The model has scaling and aggregation properties. The structure of the model depends on the structure of the graph of the controlled road network. The number of nodes in the graph is equal to the number of road sections in the considered network. The simulation of traffic flow changes in real time makes it possible to optimally determine the duration of traffic light operating phases and to provide traffic flow control with feedback based on its current state. The system of automatic collection and processing of input data for the model is presented. In order to model the states of traffic flow in the network and to solve the problem of optimal traffic flow control, the CTraf software package has been developed, a brief description of which is given in the paper. An example of the solution of the optimal control problem of traffic flows on the basis of real data in the road network of Moscow is given.

When determining therapeutic absorbed doses in the process of radioiodine therapy, the method of individual dosimetric planning is increasingly used in Russian medicine. However, for the successful implementation of this method, it is necessary to have appropriate software that allows modeling the pharmacokinetics of radioiodine in the patient’s body and calculate the necessary therapeutic activity of a radiopharmaceutical drug to achieve the planned therapeutic absorbed dose in the thyroid gland.

Purpose of the work: development of a software package for pharmacokinetic modeling and calculation of individual absorbed doses in radioiodine therapy based on a five-chamber model of radioiodine kinetics using two mathematical optimization methods. The work is based on the principles and methods of RFLP pharmacokinetics (chamber modeling). To find the minimum of the residual functional in identifying the values of the transport constants of the model, the Hook – Jeeves method and the simulated annealing method were used. Calculation of dosimetric characteristics and administered therapeutic activity is based on the method of calculating absorbed doses using the functions of radioiodine activity in the chambers found during modeling. To identify the parameters of the model, the results of radiometry of the thyroid gland and urine of patients with radioiodine introduced into the body were used.

A software package for modeling the kinetics of radioiodine during its oral intake has been developed. For patients with diffuse toxic goiter, the transport constants of the model were identified and individual pharmacokinetic and dosimetric characteristics (elimination half-lives, maximum thyroid activity and time to reach it, absorbed doses to critical organs and tissues, administered therapeutic activity) were calculated. The activity-time relationships for all cameras in the model are obtained and analyzed. A comparative analysis of the calculated pharmacokinetic and dosimetric characteristics calculated using two mathematical optimization methods was performed. Evaluation completed the stunning-effect and its contribution to the errors in calculating absorbed doses. From a comparative analysis of the pharmacokinetic and dosimetric characteristics calculated in the framework of two optimization methods, it follows that the use of a more complex mathematical method for simulating annealing in a software package does not lead to significant changes in the values of the characteristics compared to the simple Hook – Jeeves method. Errors in calculating absorbed doses in the framework of these mathematical optimization methods do not exceed the spread of absorbed dose values from the stunning-effect.

This paper targets programmers and developers interested in utilizing parallel programming techniques to enhance application performance. The Oracle Solaris Studio software provides state-of-the-art optimizing and parallelizing compilers for C, C++ and Fortran, an advanced debugger, and optimized mathematical and performance libraries. Also included are an extremely powerful performance analysis tool for profiling serial and parallel applications, a thread analysis tool to detect data races and deadlock in memory parallel programs, and an Integrated Development Environment (IDE). The Oracle Message Passing Toolkit software provides the high-performance MPI libraries and associated run-time environment needed for message passing applications that can run on a single system or across multiple compute systems connected with high performance networking, including Gigabit Ethernet, 10 Gigabit Ethernet, InfiniBand and Myrinet. Examples of OpenMP and MPI are provided throughout the paper, including their usage via the Oracle Solaris Studio and Oracle Message Passing Toolkit products for development and deployment of both serial and parallel applications on SPARC and x86/x64 based systems. Throughout this paper it is demonstrated how to develop and deploy an application parallelized with OpenMP and/or MPI.

This work deals with numerical modeling of motion of the multibody systems consisting of rigid bodies with arbitrary masses and inertial properties. We consider both planar and spatial systems which may contain kinematic loops.

The numerical modeling is fully automatic and its computational algorithm contains three principal steps. On step one a graph of the considered mechanical system is formed from the userinput data. This graph represents the hierarchical structure of the mechanical system. On step two the differential-algebraic equations of motion of the system are derived using the so-called Joint Coordinate Method. This method allows to minimize the redundancy and lower the number of the equations of motion and thus optimize the calculations. On step three the equations of motion are integrated numerically and the resulting laws of motion are presented via user interface or files.

The aforementioned algorithm is implemented in the software complex that contains a computer algebra system, a graph library, a mechanical solver, a library of numerical methods and a user interface.

Mechanical properties of eukaryotic cells play an important role in life cycle conditions and in the development of pathological processes. In this paper we discuss the problem of parameters identification and verification of viscoelastic constitutive models based on force spectroscopy data of living cells. It is proposed to use one-dimensional continuous wavelet transform to calculate the relaxation function. Analytical calculations and the results of numerical simulation are given, which allow to obtain relaxation functions similar to each other on the basis of experimentally determined force curves and theoretical stress-strain relationships using wavelet differentiation algorithms. Test examples demonstrating correctness of software implementation of the proposed algorithms are analyzed. The cell models are considered, on the example of which the application of the proposed procedure of identification and verification of their parameters is demonstrated. Among them are a structural-mechanical model with parallel connected fractional elements, which is currently the most adequate in terms of compliance with atomic force microscopy data of a wide class of cells, and a new statistical-thermodynamic model, which is not inferior in descriptive capabilities to models with fractional derivatives, but has a clearer physical meaning. For the statistical-thermodynamic model, the procedure of its construction is described in detail, which includes the following. Introduction of a structural variable, the order parameter, to describe the orientation properties of the cell cytoskeleton. Setting and solving the statistical problem for the ensemble of actin filaments of a representative cell volume with respect to this variable. Establishment of the type of free energy depending on the order parameter, temperature and external load. It is also proposed to use an oriented-viscous-elastic body as a model of a representative element of the cell. Following the theory of linear thermodynamics, evolutionary equations describing the mechanical behavior of the representative volume of the cell are obtained, which satisfy the basic thermodynamic laws. The problem of optimizing the parameters of the statisticalthermodynamic model of the cell, which can be compared both with experimental data and with the results of simulations based on other mathematical models, is also posed and solved. The viscoelastic characteristics of cells are determined on the basis of comparison with literature data.

The paper presents a software system aimed at finding best (in some sense) parameters of an algorithm. The system handles both discrete and continuous parameters and employs massive parallelism offered by public clouds. The paper presents an overview of the system, a method to measure algorithm's performance in the cloud and numerical results of system's use on several problem sets.