Contact specificity in protein-DNA complexes

Anashkina A.A., Esipova N.G., Kuznetsov E.N., Tumanyan V.G.
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In this work we investigated contacts between proteins and nucleic acids by Voronoi-Delaunay tessellation. About one third of all contacts are contacts between nucleotides and positively charged residues Arg and Lys, 32,3 %. Ser and Thr together take part in 15 % of contacts. Asn forms 6 % of contacts, as well as Gly. Contribution of each other residue type does not exceed 5 %. Statistically significant are contacts Asp-G, Trp-C, Glu-C, Asp-C and His-T. General mechanism of charged residues participation in specific protein-DNA interac-tions is suggested.

Keywords: Voronoi–Delaunay tessellation, protein-DNA complexes
Citation in English: Anashkina A.A., Esipova N.G., Kuznetsov E.N., Tumanyan V.G. Contact specificity in protein-DNA complexes // Computer Research and Modeling, 2009, vol. 1, no. 3, pp. 281-286
Citation in English: Anashkina A.A., Esipova N.G., Kuznetsov E.N., Tumanyan V.G. Contact specificity in protein-DNA complexes // Computer Research and Modeling, 2009, vol. 1, no. 3, pp. 281-286
DOI: 10.20537/2076-7633-2009-1-3-281-286
URL: http://crm-en.ics.org.ru/journal/article/1589/
Creative Commons License This work is licensed under a Creative Commons Attribution-NoDerivs 3.0 Unported License.
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