Hydrodynamical activation of blood coagulation in stenosed vessels. Theoretical analysis

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The mechanisms of hydrodynamical activation of blood coagulation system are investigated in stenosed vessels for a wide range of Reynolds number values (from 10 up to 500). It is assumed that the vessel wall permeability for procoagulant factors rapidly increases when wall shear stress exceeds specific threshold value. A number of patterns of blood coagulation processes development are described. The influence of blood flow topology changes on activation of blood coagulation is explored. It is established that not only blood flow decrease, but also its increase may promote activation of blood coagulation. It was found that dependence of thrombogenic danger of stenosis on vessel lumen blockage ratio is non-monotonic. The relevance of obtained theoretical results for clinical practice is discussed.

Keywords: mathematical modeling, blood coagulation, vessel stenosis, pattern formation
Citation in English: Rukhlenko A.S., Zlobina K.E., Guria G.T. Hydrodynamical activation of blood coagulation in stenosed vessels. Theoretical analysis // Computer Research and Modeling, 2012, vol. 4, no. 1, pp. 155-183
Citation in English: Rukhlenko A.S., Zlobina K.E., Guria G.T. Hydrodynamical activation of blood coagulation in stenosed vessels. Theoretical analysis // Computer Research and Modeling, 2012, vol. 4, no. 1, pp. 155-183
DOI: 10.20537/2076-7633-2012-4-1-155-183
According to Crossref, this article is cited by:
  • Oleksii S. Rukhlenko, Olga A. Dudchenko, Ksenia E. Zlobina, Georgy Th. Guria. Mathematical Modeling of Intravascular Blood Coagulation under Wall Shear Stress. // PLOS ONE. 2015. — V. 10, no. 7. — P. e0134028. DOI: 10.1371/journal.pone.0134028
  • A. I. Lobanov. Fibrin polymerization as a phase transition wave: A mathematical model. // Computational Mathematics and Mathematical Physics. 2016. — V. 56, no. 6. — P. 1118. DOI: 10.1134/S096554251606018X
  • Anna Arkadievna Andreeva, Andrey Vladimirovich Nikolaev, Alexey I. Lobanov. Analysis of point model of fibrin polymerization. // Computer Research and Modeling. 2017. — V. 9, no. 2. — P. 247. DOI: 10.20537/2076-7633-2017-9-2-247-258
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