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Результаты поиска по 'VIP-анализ':

Найдено статей: 1

Темлякова Е.А., Сорокин А.А.
Определение промоторных и непромоторных последовательностей E.coli по профилям их электростатического потенциала
Компьютерные исследования и моделирование, 2015, т. 7, № 2, с. 347-359

В рамках данной работыбы ла продемонстрирована возможность использования характеристик профилей электростатического потенциала вдоль последовательностей ДНК для определения их функционального класса. Построенымо дели, позволяющие разделять промоторные и непромоторные последовательности (случайные бернуллиевские, кодирующие и псевдопромоторы) с точностью порядка 83–85%. Определены наиболее значимые участки для такого разделения, по-видимому играющие важную роль при ДНК-полимеразном узнавании.

Ключевые слова: электростатические свойства ДНК, поиск промоторов, PLS–DA, VIP-анализ.

Temlyakova E.A., Sorokin A.A.
Detection of promoter and non-promoter E.coli sequences by analysis of their electrostatic profiles
Computer Research and Modeling, 2015, v. 7, no. 2, pp. 347-359

The article is devoted to the idea of using physical properties of DNA instead of sequence along for the aspect of accurate search and annotation of various prokaryotic genomic regions. Particulary, the possibility to use electrostatic potential distribution around DNA sequence as a classifier for identification of a few functional DNA regions was demonstrated. A number of classification models was built providing discrimination of promoters and non-promoter regions (random sequences, coding regions and promoter-like sequences) with accuracy value about 83–85%. The most valueable regions for the discrimination were determined and expected to play a certain role in the process of DNA-recognition by RNA-polymerase.

Keywords: electrostatics of DNA, promoter location, PLS–DA, VIP-analysis.
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International Interdisciplinary Conference "Mathematics. Computing. Education"