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Contact specificity in protein-DNA complexes
Computer Research and Modeling, 2009, v. 1, no. 3, pp. 281-286In this work we investigated contacts between proteins and nucleic acids by Voronoi-Delaunay tessellation. About one third of all contacts are contacts between nucleotides and positively charged residues Arg and Lys, 32,3 %. Ser and Thr together take part in 15 % of contacts. Asn forms 6 % of contacts, as well as Gly. Contribution of each other residue type does not exceed 5 %. Statistically significant are contacts Asp-G, Trp-C, Glu-C, Asp-C and His-T. General mechanism of charged residues participation in specific protein-DNA interac-tions is suggested.
Keywords: Voronoi–Delaunay tessellation, protein-DNA complexes.Views (last year): 2.
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