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The mathematical model of the magnetic memory cell MRAM with the in-plane anisotropy axis parallel to the edge of a free ferromagnetic layer (longitudinal anisotropy) has been constructed using approximation of uniform magnetization. The model is based on the Landau–Lifshits–Gilbert equation with the injection-current term in the Sloncžewski–Berger form. The set of ordinary differential equations for magnetization dynamics in a three-layered Co/Cu/Cu valve under the control of external magnetic field and spin-polarized current has been derived in the normal coordinate form. It was shown that the set of equations has two main stationary points on the anisotropy axis at any values of field and current. The stationary analysis of them has been performed. The algebraic equations for determination of additional stationary points have been derived. It has been shown that, depending on the field and current magnitude, the set of equations can have altogether two, four, or six stationary points symmetric in pairs relatively the anisotropy axis. The bifurcation diagrams for all the points have been constructed. The classification of the corresponding phase portraits has been performed. The typical trajectories were calculated numerically using Runge–Kutta method. The regions, where stable and unstable limit cycles exist, have been determined. It was found that the unstable limit cycles exist around the main stable equilibrium point on the axis that coincides with the anisotropy one, whereas the stable cycles surround the unstable additional points of equilibrium. The area of their existence was determined numerically. The new types of dynamics, such as accidental switching and non-complete switching, have been found. The threshold values of switching current and field have been obtained analytically. The estimations of switching times have been performed numerically.

The paper considers hereditarity oscillator which is characterized by oscillation equation with derivatives of fractional order $\beta$ and $\gamma$, which are defined in terms of Gerasimova-Caputo. Using Laplace transform were obtained analytical solutions and the Green’s function, which are determined through special functions of Mittag-Leffler and Wright generalized function. It is proved that for fixed values of $\beta = 2$ and $\gamma = 1$, the solution found becomes the classical solution for a harmonic oscillator. According to the obtained solutions were built calculated curves and the phase trajectories hereditarity oscillatory process. It was found that in the case of an external periodic influence on hereditarity oscillator may occur effects inherent in classical nonlinear oscillators.

The mathematical model of a three-layered Co/Cu/Co nanopillar for MRAM cell with one fixed and one free layer was investigated in the approximation of uniformly distributed magnetization. The anisotropy axis is perpendicular to the layers (so-called perpendicular anisotropy). Initially the magnetization of the free layer is oriented along the anisotropy axis in the position accepted to be “zero”. Simultaneous magnetic field and spinpolarized current engaging can reorient the magnetization to another position which in this context can be accepted as “one”. The mathematical description of the effect is based on the classical vector Landau–Lifshits equation with the dissipative term in the Gilbert form. In our model we took into account the interactions of the magnetization with an external magnetic field and such effective magnetic fields as an anisotropy and demagnetization ones. The influence of the spin-polarized injection current is taken into account in the form of Sloczewski–Berger term. The model was reduced to the set of three ordinary differential equations with the first integral. It was shown that at any current and field the dynamical system has two main equilibrium states on the axis coincident with anisotropy axis. It was ascertained that in contrast with the longitudinal-anisotropy model, in the model with perpendicular anisotropy there are no other equilibrium states. The stability analysis of the main equilibrium states was performed. The bifurcation diagrams characterizing the magnetization dynamics at different values of the control parameters were built. The classification of the phase portraits on the unit sphere was performed. The features of the dynamics at different values of the parameters were studied and the conditions of the magnetization reorientation were determined. The trajectories of magnetization switching were calculated numerically using the Runge–Kutta method. The parameter values at which limit cycles exist were determined. The threshold values for the switching current were found analytically. The threshold values for the structures with longitudinal and perpendicular anisotropy were compared. It was established that in the structure with the perpendicular anisotropy at zero field the switching current is an order lower than in the structure with the longitudinal one.

In this paper, a gravitational system is understood as a set of point bodies that interact according to Newton's law of attraction and have a negative value of the total energy. The question of the stability (nonstability) of a gravitational system of general position is discussed by direct computational experiment. A gravitational system of general position is a system in which the masses, initial positions, and velocities of bodies are chosen randomly from given ranges. A new method for the numerical solution of ordinary differential equations at large time intervals has been developed for the computational experiment. The proposed method allowed, on the one hand, to ensure the fulfillment of all conservation laws by a suitable correction of solutions, on the other hand, to use standard methods for the numerical solution of systems of differential equations of low approximation order. Within the framework of this method, the trajectory of a gravitational system in phase space is assembled from parts, the duration of each of which can be macroscopic. The constructed trajectory, generally speaking, is discontinuous, and the points of joining of individual pieces of the trajectory act as branch points. In connection with the latter circumstance, the proposed method, in part, can be attributed to the class of Monte Carlo methods. The general conclusion of a series of computational experiments has shown that gravitational systems of general position with a number of bodies of 3 or more, generally speaking, are unstable. In the framework of the proposed method, special cases of zero-equal angular momentum of a gravitational system with a number of bodies of 3 or more, as well as the problem of motion of two bodies, are specially considered. The case of numerical modeling of the dynamics of the solar system in time is considered separately. From the standpoint of computational experiments based on analytical methods, as well as direct numerical methods of high-order approximation (10 and higher), the stability of the solar system was previously demonstrated at an interval of five billion years or more. Due to the limitations on the available computational resources, the stability of the dynamics of the planets of the solar system within the framework of the proposed method was confirmed for a period of ten million years. With the help of a computational experiment, one of the possible scenarios for the disintegration of the solar systems is also considered.

The article presents the intermediate results of the development of a control system for a remotely piloted agricultural aircraft (RPAA). The concept of using an automated complex for performing aerochemical work (ACW) designed for processing fields, water areas, forests with the purpose of protection from pests of plants, fertilization is developed. The basic component of the complex is a manned agricultural aircraft MV-500 developed by LLC “Firm “MVEN” (Kazan). The use of the aircraft in unmanned mode will provide an increase in the productivity of the aircraft, will increase the payload.

The article defines the composition of the complex for automation of ACW: aircraft, ground control center, onboard equipment for automated control of the aircraft and the formation of a map of the heights of the section being processed, and the satellite precise positioning system necessary to automate the control of the aircraft. The aircraft is equipped with an automated control system that provides remote control of take-off and landing and automatic control of the flight trajectory at extremely low altitude when performing ACW and performing spatial turns at the boundaries of the treated areas. It is proposed to take off, landing, dropping an aircraft into the ACW exercise area by means of a pilot operator from a ground control station. The ground control point should provide reception and display on the operator's screen of flight information and several types from the aircraft. The operator can control alternately several aircraft during these phases of flight with the help of ground control authorities. In the future, it is planned to automate these stages of flight, leaving behind the pilot-operator control functions and remote control capabilities in special cases. For the navigation of the aircraft, when performing ACW on board, RTK (Real Time Kinematic) equipment is installed, providing a measurement with centimeter accuracy of coordinates and aircraft heights relative to the base station installed in the ground control station. Before the implementation of ACW, a three-dimensional digital map of the processed area is built by adding existing cadastral maps with measurements of the elevations of the section carried out with the help of on-board radio and optical altimeters of the same aircraft.

To date, the following system components have been manufactured and tested: a remotely controlled model of the MV-500 aircraft at a scale of 1:5, a satellite positioning system; system for obtaining images and telemetry information from the board model; autopilot; methods of obtaining three-dimensional digital maps of sections and planning flight trajectories for ACW.

The work is devoted to the development of a computational algorithm of the Cartesian grid method for studying the interaction of a shock wave with moving bodies with a piecewise linear boundary. The interest in such problems is connected with direct numerical simulation of two-phase media flows. The effect of the particle shape can be important in the problem of dust layer dispersion behind a passing shock wave. Experimental data on the coefficient of aerodynamic drag of non-spherical particles are practically absent.

Mathematical model is based on the two-dimensional Euler equations, which are solved in a region with varying boundaries. The defining system of equations is integrated using an explicit scheme and the Cartesian grid method. The computational algorithm at the time integration step includes: determining the step value, calculating the dynamics of the body movement (determining the force and moment acting on the body; determining the linear and angular velocities of the body; calculating the new coordinates of the body), calculating the gas parameters. At each time step, all cells are divided into two classes – external (inside the body or intersected by its boundaries) and internal (completely filled with gas). The solution of the Euler equations is constructed only in the internal ones. The main difficulty is the calculation of the numerical flux through the edges common to the internal and external cells intersected by the moving boundaries of the bodies. To calculate this flux, we use a two-wave approximation for solving the Riemann problem and the Steger-Warming scheme. A detailed description of the numerical algorithm is presented.

The efficiency of the algorithm is demonstrated on the problem of lifting a cylinder with a base in the form of a circle, ellipse and rectangle behind a passing shock wave. A circular cylinder test was considered in many papers devoted to the immersed boundary methods development. A qualitative and quantitative analysis of the trajectory of the cylinder center mass is carried out on the basis of comparison with the results of simulations presented in eight other works. For a cylinder with a base in the form of an ellipse and a rectangle, a satisfactory agreement was obtained on the dynamics of its movement and rotation in comparison with the available few literary sources. Grid convergence of the results is investigated for the rectangle. It is shown that the relative error of mass conservation law fulfillment decreases with a linear rate.

Intersections present a very demanding environment for all the parties involved. Challenges arise from complex vehicle trajectories; occasional absence of lane markings to guide vehicles; split phases that prevent determining who has the right of way; invisible vehicle approaches; illegal movements; simultaneous interactions among pedestrians, bicycles and vehicles. Unsurprisingly, most demonstrations of AVs are on freeways; but the full potential of automated vehicles — personalized transit, driverless taxis, delivery vehicles — can only be realized when AVs can sense the intersection environment to efficiently and safely maneuver through intersections.

AVs are equipped with an array of on-board sensors to interpret and suitably engage with their surroundings. Advanced algorithms utilize data streams from such sensors to support the movement of autonomous vehicles through a wide range of traffic and climatic conditions. However, there exist situations, in which additional information about the upcoming traffic environment would be beneficial to better inform the vehicles’ in-built tracking and navigation algorithms. A potential source for such information is from in-pavement sensors at an intersection that can be used to differentiate between motorized and non-motorized modes and track road user movements and interactions. This type of information, in addition to signal phasing, can be provided to the AV as it approaches an intersection, and incorporated into an improved prior for the probabilistic algorithms used to classify and track movement in the AV’s field of vision.

This paper is concerned with the situation in which there are objects that are not visible to the AV. The driving context is that of an intersection, and the lack of visibility is due to other vehicles that obstruct the AV’s view, leading to the creation of blind zones. Such obstruction is commonplace in intersections.

Our objective is:

1) inform a vehicle crossing the intersection about its potential blind zones;

2) inform the vehicle about the presence of agents (other vehicles, bicyclists or pedestrians) in those blind zones.

The COVID-19 pandemic has caused increased interest in mathematical models of the epidemic process, since only statistical analysis of morbidity does not allow medium-term forecasting in a rapidly changing situation.

Among the specific features of COVID-19 that need to be taken into account in mathematical models are the heterogeneity of the pathogen, repeated changes in the dominant variant of SARS-CoV-2, and the relative short duration of post-infectious immunity.

In this regard, solutions to a system of differential equations for a SIR class model with a heterogeneous duration of post-infectious immunity were analytically studied, and numerical calculations were carried out for the dynamics of the system with an average duration of post-infectious immunity of the order of a year.

For a SIR class model with a heterogeneous duration of post-infectious immunity, it was proven that any solution can be continued indefinitely in time in a positive direction without leaving the domain of definition of the system.

For the contact number $R_0 \leqslant 1$, all solutions tend to a single trivial stationary solution with a zero share of infected people, and for $R_0 > 1$, in addition to the trivial solution, there is also a non-trivial stationary solution with non-zero shares of infected and susceptible people. The existence and uniqueness of a non-trivial stationary solution for $R_0 > 1$ was proven, and it was also proven that it is a global attractor.

Also, for several variants of heterogeneity, the eigenvalues of the rate of exponential convergence of small deviations from a nontrivial stationary solution were calculated.

It was found that for contact number values corresponding to COVID-19, the phase trajectory has the form of a twisting spiral with a period length of the order of a year.

This corresponds to the real dynamics of the incidence of COVID-19, in which, after several months of increasing incidence, a period of falling begins. At the same time, a second wave of incidence of a smaller amplitude, as predicted by the model, was not observed, since during 2020–2023, approximately every six months, a new variant of SARS-CoV-2 appeared, which was more infectious than the previous one, as a result of which the new variant replaced the previous one and became dominant.

The paper proposes a mathematical model for the therapy of glioma, taking into account the blood-brain barrier, radiotherapy and antibody therapy. The parameters were estimated from experimental data and the evaluation of the effect of parameter values on the effectiveness of treatment and the prognosis of the disease were obtained. The possible variants of sequential use of radiotherapy and the effect of antibodies have been explored. The combined use of radiotherapy with intravenous administration of $mab$ $Cx43$ leads to a potentiation of the therapeutic effect in glioma.

Radiotherapy must precede chemotherapy, as radio exposure reduces the barrier function of endothelial cells. Endothelial cells of the brain vessels fit tightly to each other. Between their walls are formed so-called tight contacts, whose role in the provision of BBB is that they prevent the penetration into the brain tissue of various undesirable substances from the bloodstream. Dense contacts between endothelial cells block the intercellular passive transport.

The mathematical model consists of a continuous part and a discrete one. Experimental data on the volume of glioma show the following interesting dynamics: after cessation of radio exposure, tumor growth does not resume immediately, but there is some time interval during which glioma does not grow. Glioma cells are divided into two groups. The first group is living cells that divide as fast as possible. The second group is cells affected by radiation. As a measure of the health of the blood-brain barrier system, the ratios of the number of BBB cells at the current moment to the number of cells at rest, that is, on average healthy state, are chosen.

The continuous part of the model includes a description of the division of both types of glioma cells, the recovery of BBB cells, and the dynamics of the drug. Reducing the number of well-functioning BBB cells facilitates the penetration of the drug to brain cells, that is, enhances the action of the drug. At the same time, the rate of division of glioma cells does not increase, since it is limited not by the deficiency of nutrients available to cells, but by the internal mechanisms of the cell. The discrete part of the mathematical model includes the operator of radio interaction, which is applied to the indicator of BBB and to glial cells.

Within the framework of the mathematical model of treatment of a cancer tumor (glioma), the problem of optimal control with phase constraints is solved. The patient’s condition is described by two variables: the volume of the tumor and the condition of the BBB. The phase constraints delineate a certain area in the space of these indicators, which we call the survival area. Our task is to find such treatment strategies that minimize the time of treatment, maximize the patient’s rest time, and at the same time allow state indicators not to exceed the permitted limits. Since the task of survival is to maximize the patient’s lifespan, it is precisely such treatment strategies that return the indicators to their original position (and we see periodic trajectories on the graphs). Periodic trajectories indicate that the deadly disease is translated into a chronic one.

The repressilator is the first genetic regulatory network in synthetic biology, which was artificially constructed in 2000. It is a closed network of three genetic elements $lacI$, $\lambda cI$ and $tetR$, which have a natural origin, but are not found in nature in such a combination. The promoter of each of the three genes controls the next cistron via the negative feedback, suppressing the expression of the neighboring gene. In our previous paper [Bratsun et al., 2018], we proposed a mathematical model of a delayed repressillator and studied its properties within the framework of a deterministic description. We assume that delay can be both natural, i.e. arises during the transcription / translation of genes due to the multistage nature of these processes, and artificial, i.e. specially to be introduced into the work of the regulatory network using gene engineering technologies. In this work, we apply the stochastic description of dynamic processes in a delayed repressilator, which is an important addition to deterministic analysis due to the small number of molecules involved in gene regulation. The stochastic study is carried out numerically using the Gillespie algorithm, which is modified for time delay systems. We present the description of the algorithm, its software implementation, and the results of benchmark simulations for a onegene delayed autorepressor. When studying the behavior of a repressilator, we show that a stochastic description in a number of cases gives new information about the behavior of a system, which does not reduce to deterministic dynamics even when averaged over a large number of realizations. We show that in the subcritical range of parameters, where deterministic analysis predicts the absolute stability of the system, quasi-regular oscillations may be excited due to the nonlinear interaction of noise and delay. Earlier, we have discovered within the framework of the deterministic description, that there exists a long-lived transient regime, which is represented in the phase space by a slow manifold. This mode reflects the process of long-term synchronization of protein pulsations in the work of the repressilator genes. In this work, we show that the transition to the cooperative mode of gene operation occurs a two order of magnitude faster, when the effect of the intrinsic noise is taken into account. We have obtained the probability distribution of moment when the phase trajectory leaves the slow manifold and have determined the most probable time for such a transition. The influence of the intrinsic noise of chemical reactions on the dynamic properties of the repressilator is discussed.