Synchronization of circadian rhythms in the scale of a gene, a cell and a whole organism

Zakharov A.P., Bratsun D.A.
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In the paper three characteristic scales of a biological system are proposed: microscopic (gene's size), mesoscopic (cell’s size) and macroscopic level (organism’s size). For each case the approach to modeling of circadian rhythms is discussed on the base of a time-delay model. At gene’s scale the stochastic description has been used. The robustness of rhythms mechanism to the fluctuations has been demonstrated. At the mesoscopic scale we propose the deterministic description within the spatially extended model. It was found the effect of collective synchronization of rhythms in cells. Macroscopic effects have been studied within the discrete model describing the collective behaviour of large amount of cells. The problem of cross-linking of results obtained at different scales is discussed. The comparison with experimental data is given.

Keywords: circadian rhythms, synchronization, time-delay system
Citation in English: Zakharov A.P., Bratsun D.A. Synchronization of circadian rhythms in the scale of a gene, a cell and a whole organism // Computer Research and Modeling, 2013, vol. 5, no. 2, pp. 255-270
Citation in English: Zakharov A.P., Bratsun D.A. Synchronization of circadian rhythms in the scale of a gene, a cell and a whole organism // Computer Research and Modeling, 2013, vol. 5, no. 2, pp. 255-270
DOI: 10.20537/2076-7633-2013-5-2-255-270
URL: http://crm-en.ics.org.ru/journal/article/2018/
Creative Commons License This work is licensed under a Creative Commons Attribution-NoDerivs 3.0 Unported License.
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