Результаты поиска по 'bioenergetics':
Найдено статей: 2
  1. Minkevich I.G.
    The stoichiometry of metabolic pathways in the dynamics of cellular populations
    Computer Research and Modeling, 2011, v. 3, no. 4, pp. 455-475

    The problem has been considered, to what extent the kinetic models of cellular metabolism fit the matter which they describe. Foundations of stoichiometry of the whole metabolism and its large regions have been stated. A bioenergetic representation of stoichiometry based on a universal unit of chemical compound reductivity, viz., redoxon, has been described. Equations of mass-energy balance (bioenergetic variant of stoichiometry) have been derived for metabolic flows including those of protons possessing high electrochemical potential μH+, and high-energy compounds. Interrelations have been obtained which determine the biomass yield, rate of uptake of energy source for cell growth and other important physiological quantities as functions of biochemical characteristics of cellular energetics. The maximum biomass energy yield values have been calculated for different energy sources utilized by cells. These values coincide with those measured experimentally.

    Keywords: kinetic models, conservation laws, bioenergetics, biomass yield, energy source uptake rate, cell maintenance.
    Views (last year): 5. Citations: 1 (RSCI).
  2. Minkevich I.G.
    The effect of cell metabolism on biomass yield during the growth on various substrates
    Computer Research and Modeling, 2017, v. 9, no. 6, pp. 993-1014

    Bioenergetic regularities determining the maximal biomass yield in aerobic microbial growth on various substrates have been considered. The approach is based on the method of mass-energy balance and application of GenMetPath computer program package. An equation system describing the balances of quantities of 1) metabolite reductivity and 2) high-energy bonds formed and expended has been formulated. In order to formulate the system, the whole metabolism is subdivided into constructive and energetic partial metabolisms. The constructive metabolism is, in turn, subdivided into two parts: forward and standard. The latter subdivision is based on the choice of nodal metabolites. The forward constructive metabolism is substantially dependent on growth substrate: it converts the substrate into the standard set of nodal metabolites. The latter is, then, converted into biomass macromolecules by the standard constructive metabolism which is the same on various substrates. Variations of flows via nodal metabolites are shown to exert minor effects on the standard constructive metabolism. As a separate case, the growth on substrates requiring the participation of oxygenases and/or oxidase is considered. The bioenergetic characteristics of the standard constructive metabolism are found from a large amount of data for the growth of various organisms on glucose. The described approach can be used for prediction of biomass growth yield on substrates with known reactions of their primary metabolization. As an example, the growth of a yeast culture on ethanol has been considered. The value of maximal growth yield predicted by the method described here showed very good consistency with the value found experimentally.

    Keywords: biomass growth yield, cell metabolism, constructive metabolism, energetic metabolism, nodal metabolites, mass-energy balance.
    Views (last year): 17.

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