Результаты поиска по 'ion channel':
Найдено статей: 2
  1. publication_info"> Borisova M.P., Mezhevikina L.M., Petrova R.R.
    Interaction of cytokine LIF with the lipidic matrix of membranes
    Computer Research and Modeling, 2010, v. 2, no. 1, pp. 43-49

    Integration of LIF protein into the bilayer lipid membrane causes the formation of ion channels. The data on activity of ion channels formed by recombinant protein from mouse and human origin are shown. Also the difference in the effect of LIF protein from eukaryotic and prokaryotic origin is shown.

    Keywords: LIF (Leukemia Inhibitory Factor), recombinant protein, ion channel.
  2. publication_info"> Popinako A.V.
    Molecular modeling and dynamics of serotonin 5-HT3 receptor and ligands
    Computer Research and Modeling, 2011, v. 3, no. 3, pp. 329-334

    The problem of ligand binding to certain receptor proteins is of central importance in cellular signaling, but it is still unresolved at a molecular level. In order to enhance our understanding of the molecular mechanisms we used a biophysical approach to study a serotonin-gated ion channel. The molecular model of 5-HT3 receptor extracellular domain was created using computer-based homology modeling. The docking method was used for building complexes of the 5-HT3 receptor and ligands. Some different activities were investigated by the method of molecular dynamics.

    Keywords: membrane receptors, ligands, molecular dynamics.
    Citations: 1 (RSCI).

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