Результаты поиска по 'recombinant protein':
Найдено статей: 2
  1. Borisova M.P., Mezhevikina L.M., Petrova R.R.
    Interaction of cytokine LIF with the lipidic matrix of membranes
    Computer Research and Modeling, 2010, v. 2, no. 1, pp. 43-49

    Integration of LIF protein into the bilayer lipid membrane causes the formation of ion channels. The data on activity of ion channels formed by recombinant protein from mouse and human origin are shown. Also the difference in the effect of LIF protein from eukaryotic and prokaryotic origin is shown.

    Keywords: LIF (Leukemia Inhibitory Factor), recombinant protein, ion channel.
  2. Ozerov I.V., Osipov A.N.
    Kinetic model of DNA double-strand break repair in primary human fibroblasts exposed to low-LET irradiation with various dose rates
    Computer Research and Modeling, 2015, v. 7, no. 1, pp. 159-176

    Here we demonstrate the results of kinetic modeilng of DNA double-strand breaks induction and repair and phosphorilated histone H2AX ($\gamma$-H2AX) and Rad51 foci formation in primary human fibroblasts exposed to low-LET ionizing radiation (IR). The model describes two major paths of DNA double-strand breaks repair: non-homologous end joining (NHEJ) and homologous recombination (HR) and considers interactions between DNA and several repair proteins (DNA-PKcs, ATM, Ku70/80, XRCC1, XRCC4, Rad51, RPA, etc.) using mass action equations and Michaelis–Menten kinetics. Experimental data on DNA rejoining kinetics and $\gamma$-H2AX and Rad51 foci formation in vicinity of double strand breaks in primary human fibroblasts exposed to low-LET IR with various dose rates and exposure times was utilized for training and statistical validation of the model.

    Keywords: DNA double-strand breaks, DNA repair, kinetic modeling, low-LET ionizing radiation, dose rate.
    Views (last year): 4. Citations: 3 (RSCI).

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