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The paper formulates a mathematical model for hydroelastic oscillations of a plate resting on a nonlinear hardening elastic foundation and interacting with a pulsating fluid layer. The main feature of the proposed model, unlike the wellknown ones, is the joint consideration of the elastic properties of the plate, the nonlinearity of elastic foundation, as well as the dissipative properties of the fluid and the inertia of its motion. The model is represented by a system of equations for a twodimensional hydroelasticity problem including dynamics equation of Kirchhoff’s plate resting on the elastic foundation with hardening cubic nonlinearity, Navier – Stokes equations, and continuity equation. This system is supplemented by boundary conditions for plate deflections and fluid pressure at plate ends, as well as for fluid velocities at the bounding walls. The model was investigated by perturbation method with subsequent use of iteration method for the equations of thin layer of viscous fluid. As a result, the fluid pressure distribution at the plate surface was obtained and the transition to an integrodifferential equation describing bending hydroelastic oscillations of the plate is performed. This equation is solved by the Bubnov –Galerkin method using the harmonic balance method to determine the primary hydroelastic response of the plate and phase response due to the given harmonic law of fluid pressure pulsation at plate ends. It is shown that the original problem can be reduced to the study of the generalized Duffing equation, in which the coefficients at inertial, dissipative and stiffness terms are determined by the physical and mechanical parameters of the original system. The primary hydroelastic response and phases response for the plate are found. The numerical study of these responses is performed for the cases of considering the inertia of fluid motion and the creeping fluid motion for the nonlinear and linearly elastic foundation of the plate. The results of the calculations showed the need to jointly consider the viscosity and inertia of the fluid motion together with the elastic properties of the plate and its foundation, both for nonlinear and linear vibrations of the plate.

The repressor is the first genetic regulatory network in synthetic biology, which was artificially constructed in 2000. It is a closed network of three genetic elements — $lacI$, $\lambda cI$ and $tetR$, — which have a natural origin, but are not found in nature in such a combination. The promoter of each of the three genes controls the next cistron via the negative feedback, suppressing the expression of the neighboring gene. In this paper, the nonlinear dynamics of a modified repressilator, which has time delays in all parts of the regulatory network, has been studied for the first time. Delay can be both natural, i.e. arises during the transcription/translation of genes due to the multistage nature of these processes, and artificial, i.e. specially to be introduced into the work of the regulatory network using synthetic biology technologies. It is assumed that the regulation is carried out by proteins being in a dimeric form. The considered repressilator has two more important modifications: the location on the same plasmid of the gene $gfp$, which codes for the fluorescent protein, and also the presence in the system of a DNA sponge. In the paper, the nonlinear dynamics has been considered within the framework of the deterministic description. By applying the method of decomposition into fast and slow motions, the set of nonlinear differential equations with delay on a slow manifold has been obtained. It is shown that there exists a single equilibrium state which loses its stability in an oscillatory manner at certain values of the control parameters. For a symmetric repressilator, in which all three genes are identical, an analytical solution for the neutral Andronov–Hopf bifurcation curve has been obtained. For the general case of an asymmetric repressilator, neutral curves are found numerically. It is shown that the asymmetric repressor generally is more stable, since the system is oriented to the behavior of the most stable element in the network. Nonlinear dynamic regimes arising in a repressilator with increase of the parameters are studied in detail. It was found that there exists a limit cycle corresponding to relaxation oscillations of protein concentrations. In addition to the limit cycle, we found the slow manifold not associated with above cycle. This is the long-lived transitional regime, which reflects the process of long-term synchronization of pulsations in the work of individual genes. The obtained results are compared with the experimental data known from the literature. The place of the model proposed in the present work among other theoretical models of the repressilator is discussed.

Experimental, theoretical and numerical investigations of equatorial spread F, equatorial plasma bubbles (EPBs), plasma depletion shells, and plasma clouds are continued at new variety articles. Nonlinear growth, bifurcation, pinching, atomic and molecular ion dynamics are considered at there articles. But the authors of this article believe that not all parameters of EPB development are correct. For example, EPB bifurcation is highly questionable.

A maximum speed inside EPBs and a development time of EPB are defined and studied. EPBs starting from one, two or three zones of the increased density (initial plasma clouds). The development mechanism of EPB is the Rayleigh-Taylor instability (RTI). Time of the initial stage of EPB development went into EPB favorable time interval (in this case the increase linear increment is more than zero) and is 3000–7000 c for the Earth equatorial ionosphere.

Numerous computing experiments were conducted with use of the original two-dimensional mathematical and numerical model MI2, similar USA standard model SAMI2. This model MI2 is described in detail. The received results can be used both in other theoretical works and for planning and carrying out natural experiments for generation of F-spread in Earth ionosphere.

Numerical simulating was carried out for the geophysical conditions favorable for EPBs development. Numerical researches confirmed that development time of EPBs from initial irregularities with the increased density is significantly more than development time from zones of the lowered density. It is shown that developed irregularities interact among themselves strongly and not linearly even then when initial plasma clouds are strongly removed from each other. In addition, this interaction is stronger than interaction of EPBs starting from initial irregularities with the decreased density. The numerical experiments results showed the good consent of developed EPB parameters with experimental data and with theoretical researches of other authors.

The work is devoted to the study of the influence of nonlinear processes in the boundary layer on the general nature of gas flows in microchannels of technical systems. Such a study is actually concerned with nanotechnology problems. One of the important problems in this area is the analysis of gas flows in microchannels in the case of transient and supersonic flows. The results of this analysis are important for the gas-dynamic spraying techique and for the synthesis of new nanomaterials. Due to the complexity of the implementation of full-scale experiments on micro- and nanoscale, they are most often replaced by computer simulations. The efficiency of computer simulations is achieved by both the use of new multiscale models and the combination of mesh and particle methods. In this work, we use the molecular dynamics method. It is applied to study the establishment of a gas microflow in a metal channel. Nitrogen was chosen as the gaseous medium. The metal walls of the microchannels consisted of nickel atoms. In numerical experiments, the accommodation coefficients were calculated at the boundary between the gas flow and the metal wall. The study of the microsystem in the boundary layer made it possible to form a multicomponent macroscopic model of the boundary conditions. This model was integrated into the macroscopic description of the flow based on a system of quasi-gas-dynamic equations. On the basis of such a transformed gas-dynamic model, calculations of microflow in real microsystem were carried out. The results were compared with the classical calculation of the flow, which does not take into account nonlinear processes in the boundary layer. The comparison showed the need to use the developed model of boundary conditions and its integration with the classical gas-dynamic approach.

This paper provides an overview of studies on nonlinear supratransmission and related phenomena. This effect consists in the transfer of energy at frequencies not supported by the systems under consideration. The supratransmission does not depend on the integrability of the system, it is resistant to damping and various classes of boundary conditions. In addition, a nonlinear discrete medium, under certain general conditions imposed on the structure, can create instability due to external periodic influence. This instability is the generative process underlying the nonlinear supratransmission. This is possible when the system supports nonlinear modes of various nature, in particular, discrete breathers. Then the energy penetrates into the system as soon as the amplitude of the external harmonic excitation exceeds the maximum amplitude of the static breather of the same frequency.

The effect of nonlinear supratransmission is an important property of many discrete structures. A necessary condition for its existence is the discreteness and nonlinearity of the medium. Its manifestation in systems of various nature speaks of its fundamentality and significance. This review considers the main works that touch upon the issue of nonlinear supratransmission in various systems, mainly model ones.

Many teams of authors are studying this effect. First of all, these are models described by discrete equations, including sin-Gordon and the discrete Schr¨odinger equation. At the same time, the effect is not exclusively model and manifests itself in full-scale experiments in electrical circuits, in nonlinear chains of oscillators, as well as in metastable modular metastructures. There is a gradual complication of models, which leads to a deeper understanding of the phenomenon of supratransmission, and the transition to disordered structures and those with elements of chaos structures allows us to talk about a more subtle manifestation of this effect. Numerical asymptotic approaches make it possible to study nonlinear supratransmission in complex nonintegrable systems. The complication of all kinds of oscillators, both physical and electrical, is relevant for various real devices based on such systems, in particular, in the field of nano-objects and energy transport in them through the considered effect. Such systems include molecular and crystalline clusters and nanodevices. In the conclusion of the paper, the main trends in the research of nonlinear supratransmission are given.

The article deals with the nonlinear model of population dynamics of different ages workers in the regional economy. The model is built on the principles underlying modeling in econophysics. The authors demonstrate the complex dynamics of the model regimes that impose fundamental limits on medium- and long-term forecast of employment in a region. By analogy with the biophysical approach the authors propose a classification of social interactions of the different age-group workers. The model analysis is given for the level of employment among age groups. The verification of the model performs on the statistical data of the Jewish Autonomous Region.

By numerical simulation methods the interaction processes of oscillating soliton (breather) with a 180-degree Neel domain wall in the framework of a (2 + 1)-dimensional supersymmetric O(3) nonlinear sigma model is studied. The purpose of this paper is to investigate nonlinear evolution and stability of a system of interacting localized dynamic and topological solutions. To construct the interaction models, were used a stationary breather and domain wall solutions, where obtained in the framework of the two-dimensional sine-Gordon equation by adding specially selected perturbations to the A3-field vector in the isotopic space of the Bloch sphere. In the absence of an external magnetic field, nonlinear sigma models have formal Lorentz invariance, which allows constructing, in particular, moving solutions and analyses the experimental data of the nonlinear dynamics of an interacting solitons system. In this paper, based on the obtained moving localized solutions, models for incident and head-on collisions of breathers with a domain wall are constructed, where, depending on the dynamic parameters of the system, are observed the collisions and reflections of solitons from each other, a long-range interactions and also the decay of an oscillating soliton into linear perturbation waves. In contrast to the breather solution that has the dynamics of the internal degree of freedom, the energy integral of a topologically stable soliton in the all experiments the preserved with high accuracy. For each type of interaction, the range of values of the velocity of the colliding dynamic and topological solitons is determined as a function of the rotation frequency of the A3-field vector in the isotopic space. Numerical models are constructed on the basis of methods of the theory of finite difference schemes, using the properties of stereographic projection, taking into account the group-theoretical features of constructions of the O(N) class of nonlinear sigma models of field theory. On the perimeter of the two-dimensional modeling area, specially developed boundary conditions are established that absorb linear perturbation waves radiated by interacting soliton fields. Thus, the simulation of the interaction processes of localized solutions in an infinite two-dimensional phase space is carried out. A software module has been developed that allows to carry out a complex analysis of the evolution of interacting solutions of nonlinear sigma models of field theory, taking into account it’s group properties in a two-dimensional pseudo-Euclidean space. The analysis of isospin dynamics, as well the energy density and energy integral of a system of interacting dynamic and topological solitons is carried out.

The article is devoted to the numerical study of shock-wave flows in inhomogeneous media–gas mixtures. In this work, a two-speed two-temperature model is used, in which the dispersed component of the mixture has its own speed and temperature. To describe the change in the concentration of the dispersed component, the equation of conservation of “average density” is solved. This study took into account interphase thermal interaction and interphase pulse exchange. The mathematical model allows the carrier component of the mixture to be described as a viscous, compressible and heat-conducting medium. The system of equations was solved using the explicit Mac-Cormack second-order finite-difference method. To obtain a monotone numerical solution, a nonlinear correction scheme was applied to the grid function. In the problem of shock-wave flow, the Dirichlet boundary conditions were specified for the velocity components, and the Neumann boundary conditions were specified for the other unknown functions. In numerical calculations, in order to reveal the dependence of the dynamics of the entire mixture on the properties of the solid component, various parameters of the dispersed phase were considered — the volume content as well as the linear size of the dispersed inclusions. The goal of the research was to determine how the properties of solid inclusions affect the parameters of the dynamics of the carrier medium — gas. The motion of an inhomogeneous medium in a shock duct divided into two parts was studied, the gas pressure in one of the channel compartments is more important than in the other. The article simulated the movement of a direct shock wave from a high-pressure chamber to a low–pressure chamber filled with a dusty medium and the subsequent reflection of a shock wave from a solid surface. An analysis of numerical calculations showed that a decrease in the linear particle size of the gas suspension and an increase in the physical density of the material from which the particles are composed leads to the formation of a more intense reflected shock wave with a higher temperature and gas density, as well as a lower speed of movement of the reflected disturbance reflected wave.

The paper reviews possibilities to predict buckling of thin cylindrical shells with non-destructive techniques during operation. It studies shallow shells made of high strength materials. Such structures are known for surface displacements exceeding the thickness of the elements. In the explored shells relaxation oscillations of significant amplitude can be generated even under relatively low internal stresses. The problem of the cylindrical shell oscillation is mechanically and mathematically modeled in a simplified form by conversion into an ordinary differential equation. To create the model, the researches of many authors were used who studied the geometry of the surface formed after buckling (postbuckling behavior). The nonlinear ordinary differential equation for the oscillating shell matches the well-known Duffing equation. It is important that there is a small parameter before the second time derivative in the Duffing equation. The latter circumstance enables making a detailed analysis of the obtained equation and describing the physical phenomena — relaxation oscillations — that are unique to thin high-strength shells.

It is shown that harmonic oscillations of the shell around the equilibrium position and stable relaxation oscillations are defined by the bifurcation point of the solutions to the Duffing equation. This is the first point in the Feigenbaum sequence to convert the stable periodic motions into dynamic chaos. The amplitude and the period of relaxation oscillations are calculated based on the physical properties and the level of internal stresses within the shell. Two cases of loading are reviewed: compression along generating elements and external pressure.

It is highlighted that if external forces vary in time according to the harmonic law, the periodic oscillation of the shell (nonlinear resonance) is a combination of slow and stick-slip movements. Since the amplitude and the frequency of the oscillations are known, this fact enables proposing an experimental facility for prediction of the shell buckling with non-destructive techniques. The following requirement is set as a safety factor: maximum load combinations must not cause displacements exceeding specified limits. Based on the results of the experimental measurements a formula is obtained to estimate safety against buckling (safety factor) of the structure.

The repressilator is the first genetic regulatory network in synthetic biology, which was artificially constructed in 2000. It is a closed network of three genetic elements $lacI$, $\lambda cI$ and $tetR$, which have a natural origin, but are not found in nature in such a combination. The promoter of each of the three genes controls the next cistron via the negative feedback, suppressing the expression of the neighboring gene. In our previous paper [Bratsun et al., 2018], we proposed a mathematical model of a delayed repressillator and studied its properties within the framework of a deterministic description. We assume that delay can be both natural, i.e. arises during the transcription / translation of genes due to the multistage nature of these processes, and artificial, i.e. specially to be introduced into the work of the regulatory network using gene engineering technologies. In this work, we apply the stochastic description of dynamic processes in a delayed repressilator, which is an important addition to deterministic analysis due to the small number of molecules involved in gene regulation. The stochastic study is carried out numerically using the Gillespie algorithm, which is modified for time delay systems. We present the description of the algorithm, its software implementation, and the results of benchmark simulations for a onegene delayed autorepressor. When studying the behavior of a repressilator, we show that a stochastic description in a number of cases gives new information about the behavior of a system, which does not reduce to deterministic dynamics even when averaged over a large number of realizations. We show that in the subcritical range of parameters, where deterministic analysis predicts the absolute stability of the system, quasi-regular oscillations may be excited due to the nonlinear interaction of noise and delay. Earlier, we have discovered within the framework of the deterministic description, that there exists a long-lived transient regime, which is represented in the phase space by a slow manifold. This mode reflects the process of long-term synchronization of protein pulsations in the work of the repressilator genes. In this work, we show that the transition to the cooperative mode of gene operation occurs a two order of magnitude faster, when the effect of the intrinsic noise is taken into account. We have obtained the probability distribution of moment when the phase trajectory leaves the slow manifold and have determined the most probable time for such a transition. The influence of the intrinsic noise of chemical reactions on the dynamic properties of the repressilator is discussed.