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The article dwells upon investigating the issue of the most adequate tools developing and justifying to forecast the interregional migration flows value and structure. Migration processes have a significant impact on the size and demographic structure of the population of territories, the state and balance of regional and local labor markets.

To analyze the migration processes and to assess their impact an economic-mathematical tool is required which would be instrumental in modelling the migration processes and flows for different areas with the desired precision. The current methods and approaches to the migration processes modelling, including the analysis of their advantages and disadvantages, were considered. It is noted that to implement many of these methods mass aggregated statistical data is required which is not always available and doesn’t characterize the migrants behavior at the local level where the decision to move to a new dwelling place is made. This has a significant impact on the ability to apply appropriate migration processes modelling techniques and on the projection accuracy of the migration flows magnitude and structure.

The cellular automata model for interregional migration flows modelling, implementing the integration of the households migration behavior model under the conditions of the Bounded Rationality into the general model of the area migration flow was developed and tested based on the Primorye Territory data. To implement the households migration behavior model under the conditions of the Bounded Rationality the integral attractiveness index of the regions with economic, social and ecological components was proposed in the work.

To evaluate the prognostic capacity of the developed model, it was compared with the available cellular automata models used to predict interregional migration flows. The out of sample prediction method which showed statistically significant superiority of the proposed model was applied for this purpose. The model allows obtaining the forecasts and quantitative characteristics of the areas migration flows based on the households real migration behaviour at the local level taking into consideration their living conditions and behavioural motives.

The technology of creating patterns from natural language words (concepts) based on text data in the bag of words model is considered. Patterns are used to reduce the dimension of the original space in the description of documents and search for semantically related words by topic. The process of dimensionality reduction is implemented through the formation of patterns of latent features. The variety of structures of document relations is investigated in order to divide them into themes in the latent space.

It is considered that a given set of documents (objects) is divided into two non-overlapping classes, for the analysis of which it is necessary to use a common dictionary. The belonging of words to a common vocabulary is initially unknown. Class objects are considered as opposition to each other. Quantitative parameters of oppositionality are determined through the values of the stability of each feature and generalized assessments of objects according to non-overlapping sets of features.

To calculate the stability, the feature values are divided into non-intersecting intervals, the optimal boundaries of which are determined by a special criterion. The maximum stability is achieved under the condition that the boundaries of each interval contain values of one of the two classes.

The composition of features in sets (patterns of words) is formed from a sequence ordered by stability values. The process of formation of patterns and latent features based on them is implemented according to the rules of hierarchical agglomerative grouping.

A set of latent features is used for cluster analysis of documents using metric grouping algorithms. The analysis applies the coefficient of content authenticity based on the data on the belonging of documents to classes. The coefficient is a numerical characteristic of the dominance of class representatives in groups.

To divide documents into topics, it is proposed to use the union of groups in relation to their centers. As patterns for each topic, a sequence of words ordered by frequency of occurrence from a common dictionary is considered.

The results of a computational experiment on collections of abstracts of scientific dissertations are presented. Sequences of words from the general dictionary on 4 topics are formed.

In the presented work, a hybrid optimal simulation model of an assembly shop in the AnyLogic environment has been developed, which allows you to select the parameters of production systems. To build a hybrid model of the investigative approach, discrete-event modeling and aggressive modeling are combined into a single model with an integrating interaction. Within the framework of this work, a mechanism for the development of a production system consisting of several participants-agents is described. An obvious agent corresponds to a class in which a set of agent parameters is specified. In the simulation model, three main groups of operations performed sequentially were taken into account, and the logic for working with rejected sets was determined. The product assembly process is a process that occurs in a multi-phase open-loop system of redundant service with waiting. There are also signs of a closed system — scrap flows for reprocessing. When creating a distribution system in the segment, it is mandatory to use control over the execution of requests in a FIFO queue. For the functional assessment of the production system, the simulation model includes several functional functions that describe the number of finished products, the average time of preparation of products, the number and percentage of rejects, the simulation result for the study, as well as functional variables in which the calculated utilization factors will be used. A series of modeling experiments were carried out in order to study the behavior of the agents of the system in terms of the overall performance indicators of the production system. During the experiment, it was found that the indicator of the average preparation time of the product is greatly influenced by such parameters as: the average speed of the set of products, the average time to complete operations. At a given limitation interval, we managed to select a set of parameters that managed to achieve the largest possible operation of the assembly line. This experiment implements the basic principle of agent-based modeling — decentralized agents make a personal contribution and affect the operation of the entire simulated system as a whole. As a result of the experiments, thanks to the selection of a large set of parameters, it was possible to achieve high performance indicators of the assembly shop, namely: to increase the productivity indicator by 60%; reduce the average assembly time of products by 38%.

The model of the process of using machinery and equipment is considered, which takes into account the probabilistic nature of the process of their operation and sale. It takes into account the possibility of random hidden failures, after which the condition of the machine deteriorates abruptly, as well as the randomly arising need for premature (before the end of its service life) sale of the machine, which requires, generally speaking, random time. The model is focused on assessing the market value and service life of machines in accordance with International Valuation Standards. Strictly speaking, the market value of a used machine depends on its technical condition, but in practice, appraisers only take into account its age, since generally accepted measures of the technical condition of machines do not yet exist. As a result, the market value of a used machine is assumed to be equal to the average market value of similar machines of the corresponding age. For these purposes, appraisers use coefficients that reflect the influence of the age of machines on their market value. Such coefficients are not always justified and do not take into account either the degradation of the machine or the probabilistic nature of the process of its use. The proposed model is based on the anticipation of benefits principle. In it, we characterize the state of the machine by the intensity of the benefits it brings. The machine is subjected to a complex Poisson failure process, and after failure its condition abruptly worsens and may even reach its limit. Situations also arise that preclude further use of the machine by its owner. In such situations, the owner puts the machine up for sale before the end of its service life (prematurely), and the sale requires a random timing. The model allows us to take into account the influence of such situations and construct an analytical relationship linking the market value of a machine with its condition, and calculate the average coefficients of change in the market value of machines with age. At the same time, it is also possible to take into account the influence of inflation and the scrap cost of the machine. We have found that the rate of prematurely sales has a significant impact on the cost of new and used machines. The model also allows us to take into account the influence of inflation and the scrap value of the machine. We have found that the rate of premature sales has a significant impact on the service life and market value of new and used machines. At the same time, the dependence of the market value of machines on age is largely determined by the coefficient of variation of the service life of the machines. The results obtained allow us to obtain more reasonable estimates of the market value of machines, including for the purposes of the system of national accounts.

This paper is dedicated to the analysis of medical and biological data obtained through locomotor training and testing of astronauts conducted both on Earth and during spaceflight. These experiments can be described as the astronaut’s movement on a treadmill according to a predefined regimen in various speed modes. During these modes, not only the speed is recorded but also a range of parameters, including heart rate, ground reaction force, and others, are collected. In order to analyze the dynamics of the astronaut’s condition over an extended period, it is necessary to perform a qualitative segmentation of their movement modes to independently assess the target metrics. This task becomes particularly relevant in the development of an autonomous life support system for astronauts that operates without direct supervision from Earth. The segmentation of target data is complicated by the presence of various anomalies, such as deviations from the predefined regimen, arbitrary and varying duration of mode transitions, hardware failures, and other factors. The paper includes a detailed review of several contemporary retrospective (offline) nonparametric methods for detecting multiple changepoints, which refer to sudden changes in the properties of the observed time series occurring at unknown moments. Special attention is given to algorithms and statistical measures that determine the homogeneity of the data and methods for detecting change points. The paper considers approaches based on dynamic programming and sliding window methods. The second part of the paper focuses on the numerical modeling of these methods using characteristic examples of experimental data, including both “simple” and “complex” speed profiles of movement. The analysis conducted allowed us to identify the preferred methods, which will be further evaluated on the complete dataset. Preference is given to methods that ensure the closeness of the markup to a reference one, potentially allow the detection of both boundaries of transient processes, as well as are robust relative to internal parameters.

Coconut plantation plays a vital role in the economy and source of living for millions of farmers around the world, especially in tropical regions. The rugose spiraling whitefly is a highly destructive pest causing severe damage to coconut trees and significantly reducing their productivity. The aim of this paper is to develop and analyze a mathematical model that captures the dynamics of whitefly and to highlight the benefits of using biological control to mitigate the impact of pest damaging coconut palms. To be more realistic, a stage-structured model with maturation delay and lag in the implementation of the control measures has been considered in the model. We identify the equilibrium points of the system and perform a stability analysis to assess the system behavior. The numerical simulation of the proposed system is also reported. The findings reveal that introducing the population of parasitoids can effectively reduce the rugose spiraling whitefly population presenting a promising strategy for mitigating the pest’s impact.

A kinetic model of radiation-induced DNA double-strand break repair with an ultraslow component of complex damage is proposed. The model was parameterized using experimental time courses of $\gamma$H2AX and pATM foci in human mesenchymal stem cells after exposure to $\gamma$-rays (⁶⁰Co) and 14.1 MeV neutrons at a dose of 0.5 Gy. The standard two-component scheme reproduced the early response phase (0.5–6 h) but systematically underestimated the residual marker signal at 24 h, especially after neutron irradiation. Introducing an ultraslow component allowed both the early and late phases of the response to be described without fitting separate kinetic parameters for different radiation types. The differences between γ-irradiation and neutrons were introduced only through the distribution of damage between fractions, including fixed ultraslow fractions $\pi g = 0.15$ and $\pi n = 0.40$. Model comparison using $\chi^2$ and AIC, together with bootstrap analysis and local sensitivity assessment, supports the robustness of the conclusion that an ultraslow damage fraction is required to describe late post-radiation signaling.

There were presented the results of the computational and theoretical studies related to assessing of an efficacy and public health impact of a vaccination with a rotavirus vaccine in Ukraine. The required indicators are: the genotype-specific vaccine efficacy, number of the severe illness preventions, hospitalizations, outpatient visits and deaths. The results were obtained in a form of tree of decisions based on Makrov model by using mathematical model with computer simulation. The results showed the significant positive effect of the vaccination compared to no vaccination, in case of high level of vaccine coverage in Ukraine.

A simple statistical model is developed for the dynamics of the mean global annual temperature. The model combines the logarithmic effect of carbon dioxide concentration increase and the input by climatic cycles. Model parameters are determined from data of instrumental observations for 1850–2010. The model confirms the presence of climatic cycles with the period of 10.5 and 68.8 years in the global temperature dynamics. The trajectories of the global temperature changes for the XXI century are obtained under the scenarios of carbon dioxide concentration changes from the 5^th IPCC Assessment Report. The comparison revealed that the global temperature trajectories from the Report are 0.9–1.8 °C above those obtained in the model.

The paper outlines the approaches to mathematical modeling correlation adaptometry techniques widely used in biology and medicine. The analysis is based on models employed in descriptions of structured biological systems. It is assumed that the distribution density of the biological population numbers satisfies the equation of Kolmogorov-Fokker-Planck. Using this technique evaluated the effectiveness of treatment of patients with obesity. All patients depending on the obesity degree and the comorbidity nature were divided into three groups. Shows a decrease in weight of the correlation graph computed from the measured in the patients of the indicators that characterizes the effectiveness of the treatment for all studied groups. This technique was also used to assess the intensity of the training loads in academic rowing three age groups. It was shown that with the highest voltage worked with athletes for youth group. Also, using the technique of correlation adaptometry evaluated the effectiveness of the treatment of hormone replacement therapy in women. All the patients depending on the assigned drug were divided into four groups. In the standard analysis of the dynamics of mean values of indicators, it was shown that in the course of the treatment were observed normalization of the averages for all groups of patients. However, using the technique of correlation adaptometry it was found that during the first six months the weight of the correlation graph was decreasing and during the second six months the weight increased for all study groups. This indicates the excessive length of the annual course of hormone replacement therapy and the practicality of transition to a semiannual rate.