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Analysis of regional economic indicators plays a crucial role in management and development planning, with Gross Regional Product (GRP) serving as one of the key indicators of economic activity. The application of artificial intelligence, including neural network technologies, enables significant improvements in the accuracy and reliability of forecasts of economic processes. This study compares three neural network algorithm models for predicting the GRP of a typical region of the Russian Federation — the Udmurt Republic — based on time series data from 2000 to 2023. The selected models include a neural network with the Bat Algorithm (BA-LSTM), a neural network model based on backpropagation error optimized with a Genetic Algorithm (GA-BPNN), and a neural network model of Elman optimized using the Particle Swarm Optimization algorithm (PSO-Elman). The research involved stages of neural network modeling such as data preprocessing, training model, and comparative analysis based on accuracy and forecast quality metrics. This approach allows for evaluating the advantages and limitations of each model in the context of GRP forecasting, as well as identifying the most promising directions for further research. The utilization of modern neural network methods opens new opportunities for automating regional economic analysis and improving the quality of forecast assessments, which is especially relevant when data are limited and for rapid decision-making. The study uses factors such as the amount of production capital, the average annual number of labor resources, the share of high-tech and knowledge-intensive industries in GRP, and an inflation indicator as input data for predicting GRP. The high accuracy of the predictions achieved by including these factors in the neural network models confirms the strong correlation between these factors and GRP. The results demonstrate the exceptional accuracy of the BA-LSTM neural network model on validation data: the coefficient of determination was 0.82, and the mean absolute percentage error was 4.19%. The high performance and reliability of this model confirm its capacity to predict effectively the dynamics of the GRP. During the forecast period up to 2030, the Udmurt Republic is expected to experience an annual increase in Gross Regional Product (GRP) of +4.6% in current prices or +2.5% in comparable 2023 prices. By 2030, the GRP is projected to reach 1264.5 billion rubles.

In the article, a quasi-periodic two-component dynamical model with possibility of defining the cardio-cycle morphology, that provides the model with an ability of generating a temporal and a spectral cardiosignal characteristics, including heart rate variability is described. A technique for determining the cardio-cycle morphology to provide realistic cardio-signal form is defined. A method for defining cardio-signal dynamical system by the way of determining a three-dimensional state space and equations which describe a trajectory of point’s motion in this space is presented. A technique for solving equations of motion in the three-dimensional state space of dynamical cardio-signal system using the fourth-order Runge–Kutta method is presented. Based on this model, algorithm and software package are developed. Using software package, a cardio-signal synthesis experiment is conducted and the relationship of cardio-signal diagnostic features is analyzed.

In this article a method of legacy information systems handling is offered. During professional activities of specialists of various domains of industry they face with the problem that computer software that was involved in product development stage becomes obsolete much quickly than the product itself. At the same time switch to any modern software might be not possible due to various reasons. This problem is known as "legacy system" problem. It appears when product lifecycle is sufficiently longer than that of software systems that were used for product creation. In this article author offers an approach for solving this problem along with computer application based on this approach.

This article presents an integrated dynamic model of eco-economic system of the Republic of Armenia (RA). This model is constructed using system dynamics methods, which allow to consider the major feedback related to key characteristics of eco-economic system. Such model is a two-objective optimization problem where as target functions the level of air pollution and gross profit of national economy are considered. The air pollution is minimized due to modernization of stationary and mobile sources of pollution at simultaneous maximization of gross profit of national economy. At the same time considered eco-economic system is characterized by the presence of internal constraints that must be accounted at acceptance of strategic decisions. As a result, we proposed a systematic approach that allows forming sustainable solutions for the development of the production sector of RA while minimizing the impact on the environment. With the proposed approach, in particular, we can form a plan for optimal enterprise modernization and predict long-term dynamics of harmful emissions into the atmosphere.

One of the important direction of cloud technologies development nowadays is a creation of methods for integration of various cloud infrastructures. An actuality of such direction in academic field is caused by a frequent lack of own computing resources and a necessity to attract additional ones. This article is dedicated to existing approaches to cloud infrastructures integration with each other: federations and so called ‘cloud bursting’. A ‘federation’ in terms of OpenNebula cloud platform is built on a ‘one master zone and several slave ones’ schema. A term ‘zone’ means a separate cloud infrastructure in the federation. All zones in such kind of integration have a common database of users and the whole federation is managed via master zone only. Such approach is most suitable for a case when cloud infrastructures of geographically distributed branches of a single organization need to be integrated. But due to its high centralization it's not appropriate when one needs to join cloud infrastructures of different organizations. Moreover it's not acceptable at all in case of clouds based on different software platforms. A model of federative integration implemented in EGI Federated Cloud allows to connect clouds based on different software platforms but it requires a deployment of sufficient amount of additional services which are specific for EGI Federated Cloud only. It makes such approach is one-purpose and uncommon one. A ‘cloud bursting’ model has no limitations listed above but in case of OpenNebula platform what the Laboratory of Information Technologies of Joint Institute for Nuclear Research (LIT JINR) cloud infrastructure is based on such model was implemented for an integration with a certain set of commercial cloud resources providers. Taking into account an article authors’ experience in joining clouds of organizations they represent as well as with EGI Federation Cloud a ‘cloud bursting’ driver was developed by LIT JINR cloud team for OpenNebula-based clouds integration with each other as well as with OpenStack-based ones. The driver's architecture, technologies and protocols it relies on and an experience of its usage are described in the article.

Optimal management of fuel supply system boils down to choosing an energy development strategy which provides consumers with the most efficient and reliable fuel and energy supply. As a part of the program on switching the heat supply distributed management system of the Udmurt Republic to renewable energy sources, an “Information-analytical system of regional alternative fuel supply management” was developed. The paper presents the mathematical model of optimal management of fuel supply logistic system consisting of three interconnected levels: raw material accumulation points, fuel preparation points and fuel consumption points, which are heat sources. In order to increase effective the performance of regional fuel supply system a modification of information-analytical system and extension of its set of functions using the methods of quick responding when emergency occurs are required. Emergencies which occur on any one of these levels demand the management of the whole system to reconfigure. The paper demonstrates models and algorithms of optimal management in case of emergency involving break down of such production links of logistic system as raw material accumulation points and fuel preparation points. In mathematical models, the target criterion is minimization of costs associated with the functioning of logistic system in case of emergency. The implementation of the developed algorithms is based on the usage of genetic optimization algorithms, which made it possible to obtain a more accurate solution in less time. The developed models and algorithms are integrated into the information-analytical system that enables to provide effective management of alternative fuel supply of the Udmurt Republic in case of emergency.

The paper presents a comparative analysis of the enterprises of the Arctic Zone of the Russian Federation (AZ RF) on economic indicators in accordance with the rating of the Polar index. This study includes numerical data of 193 enterprises located in the AZ RF. Machine learning methods are applied, both standard, from open source, and own original methods — the method of Optimally Reliable Partitions (ORP), the method of Statistically Weighted Syndromes (SWS). Held split, indicating the maximum value of the functional quality, this study used the simplest family of different one-dimensional partition with a single boundary point, as well as a collection of different two-dimensional partition with one boundary point on each of the two combining variables. Permutation tests allow not only to evaluate the reliability of the data of the revealed regularities, but also to exclude partitions with excessive complexity from the set of the revealed regularities. Patterns connected the class number and economic indicators are revealed using the SDT method on one-dimensional indicators. The regularities which are revealed within the framework of the simplest one-dimensional model with one boundary point and with significance not worse than p < 0.001 are also presented in the given study. The so-called sliding control method was used for reliable evaluation of such diagnostic ability. As a result of these studies, a set of methods that had sufficient effectiveness was identified. The collective method based on the results of several machine learning methods showed the high importance of economic indicators for the division of enterprises in accordance with the rating of the Polar index. Our study proved and showed that those companies that entered the top Rating of the Polar index are generally recognized by financial indicators among all companies in the Arctic Zone. However it would be useful to supplement the list of indicators with ecological and social criteria.

This work is devoted to the analysis of conformational changes in tubulin dimers and tetramers, in particular, the assessment of the bending of microtubule protofilaments. Three recently exploited approaches for estimating the bend of tubulin protofilaments are reviewed: (1) measurement of the angle between the vector passing through the H7 helices in $\alpha$ and $\beta$ tubulin monomers in the straight structure and the same vector in the curved structure of tubulin; (2) measurement of the angle between the vector, connecting the centers of mass of the subunit and the associated GTP nucleotide, and the vector, connecting the centers of mass of the same nucleotide and the adjacent tubulin subunit; (3) measurement of the three rotation angles of the bent tubulin subunit relative to the straight subunit. Quantitative estimates of the angles calculated at the intra- and inter-dimer interfaces of tubulin in published crystal structures, calculated in accordance with the three metrics, are presented. Intra-dimer angles of tubulin in one structure, measured by the method (3), as well as measurements by this method of the intra-dimer angles in different structures, were more similar, which indicates a lower sensitivity of the method to local changes in tubulin conformation and characterizes the method as more robust. Measuring the angle of curvature between H7-helices (method 1) produces somewhat underestimated values of the curvature per dimer. Method (2), while at first glance generating the bending angle values, consistent the with estimates of curved protofilaments from cryoelectron microscopy, significantly overestimates the angles in the straight structures. For the structures of tubulin tetramers in complex with the stathmin protein, the bending angles calculated with all three metrics varied quite significantly for the first and second dimers (up to 20% or more), which indicates the sensitivity of all metrics to slight variations in the conformation of tubulin dimers within these complexes. A detailed description of the procedures for measuring the bending of tubulin protofilaments, as well as identifying the advantages and disadvantages of various metrics, will increase the reproducibility and clarity of the analysis of tubulin structures in the future, as well as it will hopefully make it easier to compare the results obtained by various scientific groups.

This article discusses the influence of the shadow, informal and household sectors on the dynamics of a stochastic model with heterogeneous (heterogeneous) agents. The study uses the integration of the general equilibrium approach to explain the behavior of demand, supply and prices in an economy with several interacting markets, and a multi-agent approach. The analyzed model describes an economy with aggregated uncertainty and with an infinite number of heterogeneous agents (households). The source of heterogeneity is the idiosyncratic income shocks of agents in the legal and shadow sectors of the economy. In the analysis, an algorithm is used to approximate the dynamics of the distribution function of the capital stocks of individual agents — the dynamics of its first and second moments. The synthesis of the agent approach and the general equilibrium approach is carried out using computer implementation of the recursive feedback between microagents and macroenvironment. The behavior of the impulse response functions of the main variables of the model confirms the positive influence of the shadow economy (below a certain limit) on minimizing the rate of decline in economic indicators during recessions, especially for developing economies. The scientific novelty of the study is the combination of a multi-agent approach and a general equilibrium approach for modeling macroeconomic processes at the regional and national levels. Further research prospects may be associated with the use of more detailed general equilibrium models, which allow, in particular, to describe the behavior of heterogeneous groups of agents in the entrepreneurial sector of the economy.

We consider a one-dimensional three velocity kinetic lattice Boltzmann model, which represents a secondorder difference scheme for hydrodynamic equations. In the framework of kinetic theory this system describes the propagation and interaction of three types of particles. It has been shown previously that the lattice Boltzmann model with external virtual force is equivalent at the hydrodynamic limit to the one-dimensional hemodynamic equations for elastic vessels, this equivalence can be achieved with use of the Chapman – Enskog expansion. The external force in the model is responsible for the ability to adjust the functional dependence between the lumen area of the vessel and the pressure applied to the wall of the vessel under consideration. Thus, the form of the external force allows to model various elastic properties of the vessels. In the present paper the physiological boundary conditions are considered at the inlets and outlets of the arterial network in terms of the lattice Boltzmann variables. We consider the following boundary conditions: for pressure and blood flow at the inlet of the vascular network, boundary conditions for pressure and blood flow for the vessel bifurcations, wave reflection conditions (correspond to complete occlusion of the vessel) and wave absorption at the ends of the vessels (these conditions correspond to the passage of the wave without distortion), as well as RCR-type conditions, which are similar to electrical circuits and consist of two resistors (corresponding to the impedance of the vessel, at the end of which the boundary conditions are set and the friction forces in microcirculatory bed) and one capacitor (describing the elastic properties of arterioles). The numerical simulations were performed: the propagation of blood in a network of three vessels was considered, the boundary conditions for the blood flow were set at the entrance of the network, RCR boundary conditions were stated at the ends of the network. The solutions to lattice Boltzmann model are compared with the benchmark solutions (based on numerical calculations for second-order McCormack difference scheme without viscous terms), it is shown that the both approaches give very similar results.