Результаты поиска по 'promoter':
Найдено статей: 12
  1. Temlyakova E.A., Sorokin A.A.
    Detection of promoter and non-promoter E.coli sequences by analysis of their electrostatic profiles
    Computer Research and Modeling, 2015, v. 7, no. 2, pp. 347-359

    The article is devoted to the idea of using physical properties of DNA instead of sequence along for the aspect of accurate search and annotation of various prokaryotic genomic regions. Particulary, the possibility to use electrostatic potential distribution around DNA sequence as a classifier for identification of a few functional DNA regions was demonstrated. A number of classification models was built providing discrimination of promoters and non-promoter regions (random sequences, coding regions and promoter-like sequences) with accuracy value about 83–85%. The most valueable regions for the discrimination were determined and expected to play a certain role in the process of DNA-recognition by RNA-polymerase.

    Keywords: electrostatics of DNA, promoter location, PLS–DA, VIP-analysis.
    Views (last year): 3.
  2. Rukhlenko A.S., Zlobina K.E., Guria G.T.
    Hydrodynamical activation of blood coagulation in stenosed vessels. Theoretical analysis
    Computer Research and Modeling, 2012, v. 4, no. 1, pp. 155-183

    The mechanisms of hydrodynamical activation of blood coagulation system are investigated in stenosed vessels for a wide range of Reynolds number values (from 10 up to 500). It is assumed that the vessel wall permeability for procoagulant factors rapidly increases when wall shear stress exceeds specific threshold value. A number of patterns of blood coagulation processes development are described. The influence of blood flow topology changes on activation of blood coagulation is explored. It is established that not only blood flow decrease, but also its increase may promote activation of blood coagulation. It was found that dependence of thrombogenic danger of stenosis on vessel lumen blockage ratio is non-monotonic. The relevance of obtained theoretical results for clinical practice is discussed.

    Keywords: mathematical modeling, blood coagulation, vessel stenosis, pattern formation.
    Views (last year): 2. Citations: 5 (RSCI).
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