Результаты поиска по 'reactive cell':
Найдено статей: 2
  1. Shultz D.S., Krainov A.Y.
    Mathematical modeling of SHS process in heterogeneous reactive powder mixtures
    Computer Research and Modeling, 2011, v. 3, no. 2, pp. 147-153

    In this paper we present a mathematical model and numerical results on a propagation of the combustion front of the SHS compound, where the rate of chemical reaction at each point of the SHS sample is determined by solving the problem of diffusion and chemical reaction in the reaction cell. We obtained the dependence of the combustion front on the size of the average element of a heterogeneous structure with different values of the diffusion intensity. These dependences agree qualitatively with the experimental data. We studied the effect of activation energy for diffusion on the propagation velocity of combustion front. It is revealed the propagation of the combustion front transforms to an oscillatory regime at increase in activation energy of diffusion. A transition boundary of the combustion front propagation from the steady-state regime to the oscillatory one is defined.

    Keywords: gasless burning, reactive cell, diffusion, self-propagating high temperature synthesis (SHS).
    Views (last year): 2. Citations: 5 (RSCI).
  2. Tikunova K.V., Golyshev G.G., Sokolovski S.G., Rafailov E.U., Goltsov A.N.
    Mathematical modeling of near-infrared laser irradiation effects on cancer cells
    Computer Research and Modeling, 2025, v. 17, no. 6, pp. 1205-1218

    In recent decades, the introduction of biophotonics and quantum electronics advance into medical practice led to the development of new diagnostic and therapeutic approaches for many diseases. In the field of oncology, photodynamic therapy (PDT) is successfully used today in the treatment of various types of cancer. Along with further improvement of PDT, the development of direct laser therapy is currently underway, in which the generation of singlet oxygen molecules ($^{1}$О$_2^{}$) in cancer cells occurs under NIR laser irradiation with a wavelength of $\lambda=1267$ nm without the need to introduce photosensitizers into the patient's body. For the purpose of a~theoretical investigation of the direct effect of NIR laser irradiation on cancer cells and the description of a~large set of experimental data, a mathematical model has been developed. The model includes the main cellular processes activated in cancer cells by NIR laser irradiation that determine the effectiveness of its cytotoxic effect on cancer cells. As a result of modeling, the rate of $^{1}$О$_2^{}$ generation under NIR laser irradiation was estimated, and the kinetics of active oxygen species (ROS) molecules was described. The ROS degradation due to the action of the antioxidant system of cell protection was taken into account in the model. It was shown that NIR laser irradiation induces lipid peroxidation that leads to cellular membrane damage and cell death through ferroptosis. As a result of modeling, it was established that a cascade of free-radical and enzymatic reactions of ROS transformation and accumulation leads to a prolonged response of cervical adenocarcinoma cells HeLa to the action of laser irradiation with $\lambda=1267$ nm, during which oxidative stress develops, causing cancer cell death through apoptosis and ferroptosis.

    Keywords: biophotonics, laser therapy, oncology, computer modeling, singlet oxygen, reactive oxygen species.

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