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Most biomechanical tasks of interest to clinicians can be solved only using personalized mathematical models. Such models allow to formalize and relate key pathophysiological processes, basing on clinically available data evaluate non-measurable parameters that are important for the diagnosis of diseases, predict the result of a therapeutic or surgical intervention. The use of models in clinical practice imposes additional restrictions: clinicians require model validation on clinical cases, the speed and automation of the entire calculated technological chain, from processing input data to obtaining a result. Limitations on the simulation time, determined by the time of making a medical decision (of the order of several minutes), imply the use of reduction methods that correctly describe the processes under study within the framework of reduced models or machine learning tools.

Personalization of models requires patient-oriented parameters, personalized geometry of a computational domain and generation of a computational mesh. Model parameters are estimated by direct measurements, or methods of solving inverse problems, or methods of machine learning. The requirement of personalization imposes severe restrictions on the number of fitted parameters that can be measured under standard clinical conditions. In addition to parameters, the model operates with boundary conditions that must take into account the patient’s characteristics. Methods for setting personalized boundary conditions significantly depend on the clinical setting of the problem and clinical data. Building a personalized computational domain through segmentation of medical images and generation of the computational grid, as a rule, takes a lot of time and effort due to manual or semi-automatic operations. Development of automated methods for setting personalized boundary conditions and segmentation of medical images with the subsequent construction of a computational grid is the key to the widespread use of mathematical modeling in clinical practice.

The aim of this work is to review our solutions for personalization of mathematical models within the framework of three tasks of clinical cardiology: virtual assessment of hemodynamic significance of coronary artery stenosis, calculation of global blood flow after hemodynamic correction of complex heart defects, calculating characteristics of coaptation of reconstructed aortic valve.

Laminar-turbulent transition is the subject of an active research related to improvement of economic efficiency of air vehicles, because in the turbulent boundary layer drag increases, which leads to higher fuel consumption. One of the directions of such research is the search for efficient methods, that can be used to find the position of the transition in space. Using this information about laminar-turbulent transition location when designing an aircraft, engineers can predict its performance and profitability at the initial stages of the project. Traditionally, $e^N$ method is applied to find the coordinates of a laminar-turbulent transition. It is a well known approach in industry. However, despite its widespread use, this method has a number of significant drawbacks, since it relies on parallel flow assumption, which limits the scenarios for its application, and also requires computationally expensive calculations in a wide range of frequencies and wave numbers. Alternatively, flow analysis can be done by using Dynamic Mode Decomposition, which allows one to analyze flow disturbances using flow data directly. Since Dynamic Mode Decomposition is a dimensionality reduction method, the number of computations can be dramatically reduced. Furthermore, usage of Dynamic Mode Decomposition expands the applicability of the whole method, due to the absence of assumptions about the parallel flow in its derivation.

The presented study proposes an approach to finding the location of a laminar-turbulent transition using the Dynamic Mode Decomposition method. The essence of this approach is to divide the boundary layer region into sets of subregions, for each of which the transition point is independently calculated, using Dynamic Mode Decomposition for flow analysis, after which the results are averaged to produce the final result. This approach is validated by laminar-turbulent transition predictions of subsonic and supersonic flows over a 2D flat plate with zero pressure gradient. The results demonstrate the fundamental applicability and high accuracy of the described method in a wide range of conditions. The study focuses on comparison with the $e^N$ method and proves the advantages of the proposed approach. It is shown that usage of Dynamic Mode Decomposition leads to significantly faster execution due to less intensive computations, while the accuracy is comparable to the such of the solution obtained with the $e^N$ method. This indicates the prospects for using the described approach in a real world applications.

The traditional approach to studying inter-journal communication involves analyzing journal citation graphs. This paper proposes a method for analyzing journal networks using a new type of bibliometric graph — a journal intersection graph based on the binary operation of set intersection — employing techniques grounded in the friendship index and the disparity function. The approach is demonstrated using a relatively small example of a real journal network, with data sourced from the All-Russian portal Math-Net.Ru information system: 63 journals from 2008–2021 meeting specific criteria, containing almost 69 thousand articles authored by 54 thousand individuals. The mathematical model of this real-world network is represented as an intersection graph using the Jaccard coefficient, which exhibits specific properties: low dimensionality, high graph density, and an edge weight distribution that is not approximated by a power law function. The obtained results include the network structure of connections within the studied set of journals, accounting for their degree of interaction, and the identification of significant vertices using the friendship index. This captures the graph’s structural properties, offers an obvious substantive interpretation, and allows for ranking journals by this metric. Thus, the method implements a tool for distinguishing between vertices that are leaders in terms of the friendship index and “network integrators” (based on closeness/betweenness centrality). It also demonstrates a qualitative change in structural properties when reducing graph density while maintaining connectivity, achieved by applying the disparity function. The sequential application of the disparity function while lowering the significance threshold allows for the identification of the graph’s core, containing the most strongly connected vertices. This, in turn, enables the determination of a set of vertices (and corresponding journals) that are simultaneously part of the core and have the highest significance according to the friendship index. An analysis of the levels of this resulting journal set within the “Belyi Spisok” (“White List”) shows these journals have a high rating. The findings provide a deeper understanding of the relationship structure within scientific journal networks and define new approaches for their study.

The paper presents a software system aimed at finding best (in some sense) parameters of an algorithm. The system handles both discrete and continuous parameters and employs massive parallelism offered by public clouds. The paper presents an overview of the system, a method to measure algorithm's performance in the cloud and numerical results of system's use on several problem sets.