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In molecular systems with hydrogen bonds the mechanism of proton relaxation can take place. It is caused by redistribution of protons between two steady positions in double walls potential along the line of the hydrogen bond. This redistribution occurs at change of parameters of the double walls potential of the hydrogen bond which is caused by change of an electronic state of molecular system. The relaxation process is carried out due to a tunnel transfer of protons along the line of bonds. It is shown, that relaxation process can define temperature dependence of power parameters (either of the free energy differences ΔG or of the reorganization energy λ) of charge recombination P⁺Q^-_A from RC of Rhodobacter sphaeroides.

A mathematical model for the evolution of microbial populations during prolonged cultivation in a chemostat has been constructed. This model generalizes the sequence of the well-known mathematical models of the evolution, in which such factors of the genetic variability were taken into account as chromosomal mutations, mutations in plasmid genes, the horizontal gene transfer, the plasmid loss due to cellular division and others. Liapunov’s function for the generic model of evolution is constructed. The existence proof of bounded, positive invariant and globally attracting set in the state space of the generic mathematical model for the evolution is presented because of the application of La-Salle’s theorem. The analytic description of this set is given. Numerical methods for estimate of the number of limit sets, its location and following investigation in the mathematical models for evolution are discussed.

The paper considers the problem of stationary mixed convection and heat transfer of a viscous heatconducting fluid in a plane square lid-driven cavity. The hot top cover of the cavity has any temperature $T_\mathrm{H}$ and cold bottom wall has temperature $T_\mathrm{0} (T_\mathrm{H} > T_\mathrm{0})$, whereas in contrast the side walls are insulated. The fact that the fluid density can take arbitrary values depending on the amount of overheating of the cavity cover is a feature of the problem. The mathematical formulation includes the Navier–Stokes equations in the ’velocity–pressure’ variables and the heat balance equation which take into account the incompressibility of the fluid flow and the influence of volumetric buoyancy force. The difference approximation of the original differential equations has been performed by the control volume method. Numerical solutions of the problem have been obtained on the $501 \times 501$ grid for the following values of similarity parameters: Prandtl number Pr = 0.70; Reynolds number Re = 100 and 1000; Richardson number Ri = 0.1, 1, and 10; and the relative cover overheating $(T_\mathrm{H}-T_\mathrm{0})/T_\mathrm{0} = 0, 1, 2, 3$. Detailed flow patterns in the form of streamlines and isotherms of relative overheating of the fluid flow are given in the work. It is shown that the increase in the value of the Richardson number (the increase in the influence of buoyancy force) leads to a fundamental change in the structure of the liquid stream. It is also found out that taking into account the variability of the liquid density leads to weakening of the influence of Ri growth on the transformation of the flow structure. The change in density in a closed volume is the cause of this weakening, since it always leads to the existence of zones with negative buoyancy in the presence of a volumetric force. As a consequence, the competition of positive and negative volumetric forces leads in general to weakening of the buoyancy effect. The behaviors of heat exchange coefficient (Nusselt number) and coefficient of friction along the bottom wall of the cavity depending on the parameters of the problem are also analyzed. It is revealed that the greater the values of the Richardson number are, the greater, ceteris paribus, the influence of density variation on these coefficients is.

This article presents a classification of cities, taking into account their spatial planning and possible transport solutions for cities of various types. It also discusses examples of various strategies for the development of urban public transport in Russia and the European Union with a comparison of their efficiency. The article gives examples of the impact of urban planning on mobility of citizens. To implement complex strategic decisions, it is necessary to use micro and macro models which allow a comparison of situations “as is” and “as to be” to predict consequences. In addition, the authors propose a methodology to improve public transport route network and road network, which includes determining population needs in working and educational correspondences, identifying bottlenecks in the road network, developing simulation models and developing recommendations based on the simulation results, as well as the calculation of efficiency, including the calculation of a positive social effect, economic efficiency, environmental friendliness and sustainability of the urban transport system. To prove the suggested methodology, the macro and micro models of the city under study were built taking into account the spatial planning and other specifics of the city. Thus, the case study of the city of Naberezhnye Chelny shows that the use of our methodology can help to improve the situation on the roads by optimizing the bus route network and the road infrastructure. The results showed that by implementing the proposed solutions one can decrease the amount of transport load on the bottlenecks, the number of overlapping bus routes and the traffic density.

The paper is devoted to the study of wave and relaxation effects during the pulsed outflow of a gas mixture with a high content of solid particles from a cylindrical channel during its initial partial filling. The problem is formulated in a two-speed two-temperature formulation and was solved numerically by the hybrid large-particle method of the second order of approximation. The numerical algorithm is implemented in the form of parallel computing using basic Free Pascal language tools. The applicability and accuracy of the method for wave flows of concentrated gas-particles mixtures is confirmed by comparison with test asymptotically accurate solutions. The calculation error on a grid of low detail in the characteristic flow zones of a two-phase medium was 10^-6 . . . 10^-5.

Based on the wave diagram, the analysis of the physical pattern of the outflow of a gas suspension partially filling a cylindrical channel is performed. It is established that, depending on the degree of initial filling of the channel, various outflow modes are formed. The first mode is implemented with a small degree of loading of the high-pressure chamber, at which the left boundary of the gas-particles mixture crosses the outlet section before the arrival of the rarefaction wave reflected from the bottom of the channel. At the same time, the maximum value of the mass flow rate of the mixture is achieved. Other modes are formed in cases of a larger initial filling of the channel, when the rarefaction waves reflected from the bottom of the channel interact with the gas suspension layer and reduce the intensity of its outflow.

The influence of relaxation properties with changing particle size on the dynamics of a limited layer of a gas-dispersed medium is studied. Comparison of the outflow of a limited gas suspension layer with different particle sizes shows that for small particles (the Stokes number is less than 0.001), an anomalous phenomenon of the simultaneous existence of shock wave structures in the supersonic and subsonic flow of gas and suspension is observed. With an increase in the size of dispersed inclusions, the compaction jumps in the region of the two-phase mixture are smoothed out, and for particles (the Stokes number is greater than 0.1), they practically disappear. At the same time, the shock-wave configuration of the supersonic gas flow at the outlet of the channel is preserved, and the positions and boundaries of the energy-carrying volumes of the gas suspension are close when the particle sizes change.

We derive a new model of circadian oscillations in Neurospora crassa, which is suitable to analyze both temporal and spatial dynamics of proteins responsible for mechanism of rythms. The model is based on the non-linear interplay between proteins FRQ and WCC which are products of transcription of frequency and white collar genes forming a feedback loop comprised both positive and negative elements. The main component of oscillations mechanism is supposed to be time-delay in biochemical reactions of transcription. We show that the model accounts for various features observed in Neurospora’s experiments such as entrainment by light cycles, phase shift under light pulse, robustness to action of fluctuations and so on. Wave patterns excited during spatial development of the system are studied. It is shown that the wave of synchronization of biorythms arises under basal transcription factors.

In this paper, we propose an adaptive algorithm that simulates the process of forming the initial behavioral skills on the example of the system ‘eye-arm’ animat. The situation is the formation of the initial behavioral skills occurs, for example, when a child masters the management of their hands by understanding the relationship between baseline unidentified spots on the retina of his eye and the position of the real object. Since the body control skills are not ‘hardcoded’ initially in the brain and the spinal cord at the level of instincts, the human child, like most young of other mammals, it is necessary to develop these skills in search behavior mode. Exploratory behavior begins with trial and error and then its contribution is gradually reduced as the development of the body and its environment. Since the correct behavior patterns at this stage of development of the organism does not exist for now, then the only way to select the right skills is a positive reinforcement to achieve the objective. A key feature of the proposed algorithm is to fix in the imprinting mode, only the final action that led to success, and that is very important, led to the familiar imprinted situation clearly leads to success. Over time, the continuous chain is lengthened right action — maximum use of previous positive experiences and negative ‘forgotten’ and not used.

Thus there is the gradual replacement of the random search purposeful actions that observed in the real young. Thus, the algorithm is able to establish a correspondence between the laws of the world and the ‘inner feelings’, the internal state of the animat. The proposed animat model was used 2 types of neural networks: 1) neural network NET1 to the input current which is fed to the position of the brush arms and the target point, and the output of motor commands, directing ‘brush’ manipulator animat to the target point; 2) neural network NET2 is received at the input of target coordinates and the current coordinates of the ‘brush’ and the output value is formed likelihood that the animat already ‘know’ this situation, and he ‘knows’ how to react to it. With this architecture at the animat has to rely on the ‘experience’ of neural networks to recognize situations where the response from NET2 network of close to 1, and on the other hand, run a random search, when the experience of functioning in this area of the visual field in animat not (response NET2 close to 0).

The article is devoted to the effect of thermal feedback, which occurs during the operation of integrated circuits and electronic systems with their use. Thermal feedback is due to the fact that the power consumed by the functioning of the microchip heats it and, due to the significant dependence of its electrical parameters on temperature, interactive interaction arises between its electrical and thermal processes. The effect of thermal feedback leads to a change in both electrical parameters and temperature levels in microcircuits. Positive thermal feedback is an undesirable phenomenon, because it causes the output of the electrical parameters of the microcircuits beyond the permissible values, the reduction in reliability and, in some cases, burn out. Negative thermal feedback is manifested in stabilizing the electrical and thermal regimes at lower temperature levels. Therefore, when designing microcircuits and electronic systems with their application, it is necessary to achieve the implementation of negative feedback. In this paper, we propose a method for modeling of thermal modes in electronic systems, taking into account the effect of thermal feedback. The method is based on introducing into the thermal model of the electronic system new model circuit elements that are nonlinearly dependent on temperature, the number of which is equal to the number of microcircuits in the electronic system. This approach makes it possible to apply matrix-topological equations of thermal processes to the thermal model with new circuit elements introduced into it and incorporate them into existing thermal design software packages. An example of modeling a thermal process in a real electronic system is presented, taking into account the effect of thermal feedback on the example of a microcircuit installed on a printed circuit board. It is shown that in order to adequately model the electrical and thermal processes of microcircuits and electronic systems, it is necessary to take into account the effects of thermal feedback in order to avoid design errors and create competitive electronic systems.

The utilization of unmanned aerial vehicles (UAVs) in high-rise firefighting operations is the right solution for reaching the fire scene on high floors quickly and effectively. The article proposes a quadrotor-type firefighting UAV model carrying a launcher to launch a missile containing fire extinguishing powders into a fire. The kinematic model describing the flight kinematics of this UAV model is built based on the Newton – Euler method when the device is in normal motion and at the time of launching a firefighting missile. The results from the simulation testing the validity of the kinematic model and the simulation of the motion of the UAV show that the variation of Euler angles, flight angles, and aerodynamic angles during a flight are within an acceptable range and overload guarantee in flight. The UAV flew to the correct position to launch the required fire-extinguishing ammunition. The results of the research are the basis for building a control system of high-rise firefighting drones in Vietnam.

In this work, we develop a model of the immune response to respiratory viral infections taking into account some particular properties of the SARS-CoV-2 infection. The model represents a system of ordinary differential equations for the concentrations of epithelial cells, immune cells, virus and inflammatory cytokines. Conventional analysis of the existence and stability of stationary points is completed by numerical simulations in order to study dynamics of solutions. Behavior of solutions is characterized by large peaks of virus concentration specific for acute respiratory viral infections.

At the first stage, we study the innate immune response based on the protective properties of interferon secreted by virus-infected cells. On the other hand, viral infection down-regulates interferon production. Their competition can lead to the bistability of the system with different regimes of infection progression with high or low intensity. In the case of infection outbreak, the incubation period and the maximal viral load depend on the initial viral load and the parameters of the immune response. In particular, increase of the initial viral load leads to shorter incubation period and higher maximal viral load.

In order to study the emergence and dynamics of cytokine storm, we consider proinflammatory cytokines produced by cells of the innate immune response. Depending on parameters of the model, the system can remain in the normal inflammatory state specific for viral infections or, due to positive feedback between inflammation and immune cells, pass to cytokine storm characterized by excessive production of proinflammatory cytokines. Furthermore, inflammatory cell death can stimulate transition to cytokine storm. However, it cannot sustain it by itself without the innate immune response. Assumptions of the model and obtained results are in qualitative agreement with the experimental and clinical data.