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Most biomechanical tasks of interest to clinicians can be solved only using personalized mathematical models. Such models allow to formalize and relate key pathophysiological processes, basing on clinically available data evaluate non-measurable parameters that are important for the diagnosis of diseases, predict the result of a therapeutic or surgical intervention. The use of models in clinical practice imposes additional restrictions: clinicians require model validation on clinical cases, the speed and automation of the entire calculated technological chain, from processing input data to obtaining a result. Limitations on the simulation time, determined by the time of making a medical decision (of the order of several minutes), imply the use of reduction methods that correctly describe the processes under study within the framework of reduced models or machine learning tools.

Personalization of models requires patient-oriented parameters, personalized geometry of a computational domain and generation of a computational mesh. Model parameters are estimated by direct measurements, or methods of solving inverse problems, or methods of machine learning. The requirement of personalization imposes severe restrictions on the number of fitted parameters that can be measured under standard clinical conditions. In addition to parameters, the model operates with boundary conditions that must take into account the patient’s characteristics. Methods for setting personalized boundary conditions significantly depend on the clinical setting of the problem and clinical data. Building a personalized computational domain through segmentation of medical images and generation of the computational grid, as a rule, takes a lot of time and effort due to manual or semi-automatic operations. Development of automated methods for setting personalized boundary conditions and segmentation of medical images with the subsequent construction of a computational grid is the key to the widespread use of mathematical modeling in clinical practice.

The aim of this work is to review our solutions for personalization of mathematical models within the framework of three tasks of clinical cardiology: virtual assessment of hemodynamic significance of coronary artery stenosis, calculation of global blood flow after hemodynamic correction of complex heart defects, calculating characteristics of coaptation of reconstructed aortic valve.

We'd like to present a specific grid infrastructure and web application development and deployment. The purpose of infrastructure and web application is to solve particular geophysical problems that require heavy computational resources. Here we cover technology overview and connector framework internals. The connector framework links problem-specific routines with middleware in a manner that developer of application doesn't have to be aware of any particular grid software. That is, the web application built with this framework acts as an interface between the user 's web browser and Grid's (often very) own middleware.

Our distributed computing system is built around Gridway metascheduler. The metascheduler is connected to TORQUE resource managers of virtual compute nodes that are being run atop of compute cluster utilizing the virtualization technology. Such approach offers several notable features that are unavailable to bare-metal compute clusters.

The first application we've integrated with our framework is seismic anisotropic parameters determination by inversion of SKS and converted phases. We've used probabilistic approach to inverse problem solution based on a posteriory probability distribution function (APDF) formalism. To get the exact solution of the problem we have to compute the values of multidimensional function. Within our implementation we used brute-force APDF calculation on rectangular grid across parameter space.

The result of computation is stored in relational DBMS and then represented in familiar human-readable form. Application provides several instruments to allow analysis of function's shape by computational results: maximum value distribution, 2D cross-sections of APDF, 2D marginals and a few other tools. During the tests we've run the application against both synthetic and observed data.

One of the most widely used storage solutions in WLCG is a Disk Pool Manager (DPM) developed and supported by SDC/ID group at CERN. Recently DPM went through a massive overhaul to address scalability and extensibility issues of the old code.

New system was called DMLite. Unlike the old DPM that was based on daemons, DMLite is arranged as a library that can be loaded directly by an application. This approach greatly improves performance and transaction rate by avoiding unnecessary inter-process communication via network as well as threading bottlenecks.

DMLite has a modular architecture with its core library providing only the very basic functionality. Backends (storage engines) and frontends (data access protocols) are implemented as plug-in modules. Doubtlessly DMLite wouldn't be able to completely replace DPM without GridFTP as it is used for most of the data transfers in WLCG.

In DPM GridFTP support was implemented in a Data Storage Interface (DSI) module for Globus’ GridFTP server. In DMLite an effort was made to rewrite a GridFTP module from scratch in order to take advantage of new DMLite features and also implement new functionality. The most important improvement over the old version is a redirection capability.

With old GridFTP frontend a client needed to contact SRM on the head node in order to obtain a transfer URL (TURL) before reading or writing a file. With new GridFTP frontend this is no longer necessary: a client may connect directly to the GridFTP server on the head node and perform file I/O using only logical file names (LFNs). Data channel is then automatically redirected to a proper disk node.

This renders the most often used part of SRM unnecessary, simplifies file access and improves performance. It also makes DMLite a more appealing choice for non-LHC VOs that were never much interested in SRM.

With new GridFTP frontend it's also possible to access data on various DMLite-supported backends like HDFS, S3 and legacy DPM.

The approach to build territorial distributed storage system for high performance computing environment of UB RAS is presented. The storage system is based on the dCache middleware from the European Middleware Initiative project. The first milestone of distributed storage system implementation includes the data centers at the two UB RAS Regions: Yekaterinburg and Perm.

Volunteer computing resembles private desktop grids whereas desktop grids are not fully equivalent to volunteer computing. There are several attempts to distinguish and categorize them using informal and formal methods. However, most formal approaches model a particular middleware and do not focus on the general notion of volunteer or desktop grid computing. This work makes an attempt to formalize their characteristics and relationship. To this end formal modeling is applied that tries to grasp the semantic of their functionalities — as opposed to comparisons based on properties, features, etc. We apply this modeling method to formalize the Berkeley Open Infrastructure for Network Computing (BOINC) [Anderson D. P., 2004] volunteer computing system.

The review of the distributed computing infrastructure of the Tier-1 sites for the Alice, ATLAS, LHCb experiments at the LHC is given. The special emphasis is placed on the main tasks and services of the Tier-1 site, which operates in the Kurchatov Institute in Moscow.

Grid is a new type of computing infrastructure, is intensively developed in today world of information technologies. Grid provides global integration of information and computing resources. The essence Conception of GRID in Azerbaijan is to create a set of standardized services to provide a reliable, compatible, inexpensive and secure access to geographically distributed high-tech information and computing resources a separate computer, cluster and supercomputing centers, information storage, networks, scientific tools etc.

The technique of ensuring of interoperability for Grid-systems and systems of cloud computing is provided. The technique is constructed on a basis of the uniform approach of ensuring interoperability for systems of the wide class offered by authors and recorded in the national Russian Federation standard.

The paper presents a new grid and cloud services simulation system. This system is developed in LIT JINR, Dubna, and it is aimed at improving the efficiency of the grid-cloud systems development by using work quality indicators of some real system to design and predict its evolution. For these purpose, simulation program is combined with real monitoring system of the grid-cloud service through a special database. The paper provides an example of the program usage to simulate a sufficiently general cloud structure, which can be used for more common purposes.

In the design of a distributed library system, there are a lot of organizational problems, ideas, solutions which are the subject of this article. The article presents the approaches on crowd funding platforms that are used as a tool for attracting participants and financing project.