All issues

We have investigated dynamics of synthetic genetic oscillators — repressilators — coupled through autoinducer diffusion. The model of the system with phase-repulsive coupling structure is under consideration. We have examined emergence of periodic regimes, stable inhomogeneous steady states depending on the main systems’ parameters: coupling strength and maximal transcription rate. It has been shown that autoinducer production module added to the isolated repressilator cause the limit cycle to disappear through infinite period bifurcation for sufficiently large transcription rate. We have found hysteresis of limit cycle and stable steady state the size of which is determined by ratio between mRNA and protein lifetimes. Two coupled oscillators system demonstrates stable anti-phase oscillations which can become a chaotic regime through invariant torus emergence or via Feigenbaum scenario.

We consider the hierarchical model of financial crashes introduced by A. Johansen and D. Sornette which reproduces the log-periodic power law behavior of the price before the critical point. In order to build the generalization of this model we introduce the dependence of an influence exponent on an ultrametric distance between agents. Much attention is being paid to a problem of critical point universality which is investigated by comparison of probability density functions of the crash times corresponding to systems with various total numbers of agents.

The dynamics of coupled elements’ ensembles are investigated in the context of description of spatio-temporal processes in the myocardium. Basic element is map-based model constructed by simplification and reduction of Luo-Rudy model. In particular, capabilities of the model in replication of different regimes of cardiac activity are shown, including excitable and oscillatory regimes. The dynamics of 1D and 2D lattices of coupled oscillatory elements with a random distribution of individual frequencies are considered. Effects of cluster synchronization and transition to global synchronization by increasing of coupling strength are discussed. Impulse propagation in the chain of excitable cells has been observed. Analysis of 2D lattice of excitable elements with target and spiral waves have been made. The characteristics of the spiral wave has been analyzed in depending on the individual parameters of the map and coupling strength between elements of the lattice. A study of mixed ensembles consisting of excitable and oscillatory elements with a gradient changing of the properties have been made, including the task for description of normal and pathological activity of the sinoatrial node.

We study the centrally symmetric mathematical model of electrodiffusion. This model describes in particular the transport of the Li⁺ ions in certain electrochemical current sources. We demonstrate that the steady state solution of the considered model exists and is unique if the boundary values of the ion concentration and electric potential are given. This solution also proves to be the stable attractor of the time-dependent solutions with different initial value distributions.

This article describes an experience of LIT JINR team in application software packages adaptation for running in different grid environments. Peculiarities of the applications “gridification” depending on their possible launch modes and a type of the matching computational resources are given. The particular applications and grid environments which applications are adopted for are listed.

Work is devoted to modeling instrumental errors of a laser beam diameter measurement using a method based on a lambertian transmissive screen. Super-Lorenz distribution was used as a model of the beam. To determine the effect of each parameter on the measurement error were performed computational experiments, results of which were approximated by analytic functions. There were obtained the errors depending on relative beam size, spatial non-uniformity of the transmission screen, lens distortion, physical vignetting, beam tilt, CCD spatial resolution, ADC resolution of a camera. There was shown that the error can be less then 1 %.

The course and outcome of the battle is largely dependent on the morale of the troops, characterized by the percentage of loss in killed and wounded, in which the troops still continue to fight. Every fight is a psychological act of ending his rejection of one of the parties. Typically, models of battle psychological factor taken into account in the decision of Lanchester equations (the condition of equality of forces, when the number of one of the parties becomes zero). It is emphasized that the model Lanchester type satisfactorily describe the dynamics of the battle only in the initial stages. To resolve this contradiction is proposed to use a modification of Lanchester's equations, taking into account the fact that at any moment of the battle on the enemy firing not affected and did not abandon the battle fighters. The obtained differential equations are solved by numerical method and allow the dynamics to take into account the influence of psychological factor and evaluate the completion time of the conflict. Computational experiments confirm the known military theory is the fact that the fight usually ends in refusal of soldiers of one of the parties from its continuation (avoidance of combat in various forms). Along with models of temporal and spatial dynamics proposed to use a modification of the technology features of the conflict of S. Skaperdas, based on the principles of combat. To estimate the probability of victory of one side in the battle takes into account the interest of the maturing sides of the bloody casualties and increased military superiority.

An approach to numerical analysis of thermo-hydraulic processes proceeding in a fast-neutron reactor is described in the given article. The description covers physical models, numerical schemes and geometry simplifications accepted in the computational model. Steady-state and dynamic regimes of reactor operation are considered. The steady-state regimes simulate the reactor operation at nominal power. The dynamic regimes simulate the shutdown reactor cooling by means of the heat-removal system.

Simulation of thermo-hydraulic processes is carried out in the FlowVision CFD software. A mathematical model describing the coolant flow in the first loop of the fast-neutron reactor was developed on the basis of the available geometrical model. The flow of the working fluid in the reactor simulator is calculated under the assumption that the fluid density does not depend on pressure, with use a $k–\varepsilon$ turbulence model, with use of a model of dispersed medium, and with account of conjugate heat exchange. The model of dispersed medium implemented in the FlowVision software allowed taking into account heat exchange between the heat-exchanger lops. Due to geometric complexity of the core region, the zones occupied by the two heat exchangers were modeled by hydraulic resistances and heat sources.

Numerical simulation of the coolant flow in the FlowVision software enabled obtaining the distributions of temperature, velocity and pressure in the entire computational domain. Using the model of dispersed medium allowed calculation of the temperature distributions in the second loops of the heat exchangers. Besides that, the variation of the coolant temperature along the two thermal probes is determined. The probes were located in the cool and hot chambers of the fast-neutron reactor simulator. Comparative analysis of the numerical and experimental data has shown that the developed mathematical model is correct and, therefore, it can be used for simulation of thermo-hydraulic processes proceeding in fast-neutron reactors with sodium coolant.

The paper proposes an approach to simulation of a sport game, consisting of a discrete set of separate competitions. According to this approach, such a competition is considered as a random processes, generally — a non-Markov’s one. At first we treat the flow of the game as a Markov’s process, obtaining recursive relationship between the probabilities of achieving certain states of score in a tennis match, as well as secondary indicators of the game, such as expectation and variance of the number of serves to finish the game. Then we use a simulation system, modeling the match, to allow an arbitrary change of the probabilities of the outcomes in the competitions that compose the match. We, for instance, allow the probabilities to depend on the results of previous competitions. Therefore, this paper deals with a modification of the model, previously proposed by the authors for sports games with continuous time.

The proposed approach allows to evaluate not only the probability of the final outcome of the match, but also the probabilities of reaching each of the possible intermediate results, as well as secondary indicators of the game, such as the number of separate competitions it takes to finish the match. The paper includes a detailed description of the construction of a simulation system for a game of a tennis match. Then we consider simulating a set and the whole tennis match by analogy. We show some statements concerning fairness of tennis serving rules, understood as independence of the outcome of a competition on the right to serve first. We perform simulation of a cancelled ATP series match, obtaining its most probable intermediate and final outcomes for three different possible variants of the course of the match.

The main result of this paper is the developed method of simulation of the match, applicable not only to tennis, but also to other types of sports games with discrete time.

In case of vessel wall damage or contact of blood plasma with a foreign surface, the chain of chemical reactions called coagulation cascade is launched that leading to the formation of a fibrin clot. A key enzyme of the coagulation cascade is thrombin, which catalyzes formation of fibrin from fibrinogen. The distribution of thrombin concentration in blood plasma determines spatio-temporal dynamics of clot formation. Contact pathway of blood coagulation triggers the production of thrombin in response to the contact with a negatively charged surface. If the concentration of thrombin generated at this stage is large enough, further production of thrombin takes place due to positive feedback loops of the coagulation cascade. As a result, thrombin propagates in plasma cleaving fibrinogen that results in the clot formation. The concentration profile and the speed of propagation of thrombin are constant and do not depend on the type of the initial activator.

Such behavior of the coagulation system is well described by the traveling wave solutions in a system of “reaction – diffusion” equations on the concentration of blood factors involved in the coagulation cascade. In this study, we carried out detailed analysis of the mathematical model describing the main reaction of the intrinsic pathway of coagulation cascade.We formulate necessary and sufficient conditions of the existence of the traveling wave solutions. For the considered model the existence of such solutions is equivalent to the existence of the wave solutions in the simplified one-equation model describing the dynamics of thrombin concentration derived under the quasi-stationary approximation.

Simplified model also allows us to obtain analytical estimate of the thrombin propagation rate in the considered model. The speed of the traveling wave for one equation is estimated using the narrow reaction zone method and piecewise linear approximation. The resulting formulas give a good approximation of the velocity of propagation of thrombin in the simplified, as well as in the original model.