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The possibility of numerical 3D simulation of thrombi formation is considered.

The developed up to now detailed mathematical models describing formation of thrombi and clots include a great number of equations. Being implemented in a CFD code, the detailed mathematical models require essential computer resources for simulation of the thrombi growth in a blood flow. A reasonable alternative way is using reduced mathematical models. Two models based on the reduced mathematical model for the thrombin generation are described in the given paper.

The first model describes growth of a thrombus in a great vessel (artery). The artery flows are essentially unsteady. They are characterized by pulse waves. The blood velocity here is high compared to that in the vein tree. The reduced model for the thrombin generation and the thrombus growth in an artery is relatively simple. The processes accompanying the thrombin generation in arteries are well described by the zero-order approximation.

A vein flow is characterized lower velocity value, lower gradients, and lower shear stresses. In order to simulate the thrombin generation in veins, a more complex system of equations has to be solved. The model must allow for all the non-linear terms in the right-hand sides of the equations.

The simulation is carried out in the industrial software FlowVision.

The performed numerical investigations have shown the suitability of the reduced models for simulation of thrombin generation and thrombus growth. The calculations demonstrate formation of the recirculation zone behind a thrombus. The concentration of thrombin and the mass fraction of activated platelets are maximum here. Formation of such a zone causes slow growth of the thrombus downstream. At the upwind part of the thrombus, the concentration of activated platelets is low, and the upstream thrombus growth is negligible.

When the blood flow variation during a hart cycle is taken into account, the thrombus growth proceeds substantially slower compared to the results obtained under the assumption of constant (averaged over a hard cycle) conditions. Thrombin and activated platelets produced during diastole are quickly carried away by the blood flow during systole. Account of non-Newtonian rheology of blood noticeably affects the results.

Virtual machines are usually associated with an ability to create them on demand by calling web services, then these machines are used to deliver resident services to their clients; however, providing clients with an ability to run an arbitrary programme on the newly created machines is beyond their power. Such kind of usage is useful in a high performance computing environment where most of the resources are consumed by batch programmes and not by daemons or services. In this case a cluster of virtual machines is created on demand to run a distributed or parallel programme and to save its output to a network attached storage. Upon completion this cluster is destroyed and resources are released. With certain modifications this approach can be extended to interactively deliver computational resources to the user thus providing virtual desktop as a service. Experiments show that the process of creating virtual clusters on demand can be made efficient in both cases.

Laminar-turbulent transition is the subject of an active research related to improvement of economic efficiency of air vehicles, because in the turbulent boundary layer drag increases, which leads to higher fuel consumption. One of the directions of such research is the search for efficient methods, that can be used to find the position of the transition in space. Using this information about laminar-turbulent transition location when designing an aircraft, engineers can predict its performance and profitability at the initial stages of the project. Traditionally, $e^N$ method is applied to find the coordinates of a laminar-turbulent transition. It is a well known approach in industry. However, despite its widespread use, this method has a number of significant drawbacks, since it relies on parallel flow assumption, which limits the scenarios for its application, and also requires computationally expensive calculations in a wide range of frequencies and wave numbers. Alternatively, flow analysis can be done by using Dynamic Mode Decomposition, which allows one to analyze flow disturbances using flow data directly. Since Dynamic Mode Decomposition is a dimensionality reduction method, the number of computations can be dramatically reduced. Furthermore, usage of Dynamic Mode Decomposition expands the applicability of the whole method, due to the absence of assumptions about the parallel flow in its derivation.

The presented study proposes an approach to finding the location of a laminar-turbulent transition using the Dynamic Mode Decomposition method. The essence of this approach is to divide the boundary layer region into sets of subregions, for each of which the transition point is independently calculated, using Dynamic Mode Decomposition for flow analysis, after which the results are averaged to produce the final result. This approach is validated by laminar-turbulent transition predictions of subsonic and supersonic flows over a 2D flat plate with zero pressure gradient. The results demonstrate the fundamental applicability and high accuracy of the described method in a wide range of conditions. The study focuses on comparison with the $e^N$ method and proves the advantages of the proposed approach. It is shown that usage of Dynamic Mode Decomposition leads to significantly faster execution due to less intensive computations, while the accuracy is comparable to the such of the solution obtained with the $e^N$ method. This indicates the prospects for using the described approach in a real world applications.

Methods for modeling blood flow and its rheological properties are reviewed. Blood is considered as a particle suspencion. The methods are boundary integral equation method (BIEM), lattice Boltzmann (LBM), finite elements on dynamic mesh, dissipative particle dynamics (DPD) and agent based modeling. The analysis of these methods’ applications on high-performance systems with various architectures is presented.

The approach to build territorial distributed storage system for high performance computing environment of UB RAS is presented. The storage system is based on the dCache middleware from the European Middleware Initiative project. The first milestone of distributed storage system implementation includes the data centers at the two UB RAS Regions: Yekaterinburg and Perm.

Big science projects are producing data at ever increases rates. Typical techniques involve storing the data to disk, after minor filtering, and then processing it in large computer farms. Data production has reached a point where on-line processing is required in order to filter the data down to manageable sizes. A potential solution involves using low-cost, low-power ARM processors in large arrays to provide massive parallelisation for data stream computing (DSC). The main advantage in using System on Chips (SoCs) is inherent in its design philosophy. SoCs are primarily used in mobile devices and hence consume less power while maintaining relatively good performance. A benchmarking characterisation of three different models of ARM processors will be presented.

Computational intensity is traditionally the focus of large-scale computing system designs, generally leaving such designs ill-equipped to efficiently handle throughput-oriented workloads. In addition, cost and energy consumption considerations for large-scale computing systems in general remain a source of concern. A potential solution involves using low-cost, low-power ARM processors in large arrays in a manner which provides massive parallelisation and high rates of data throughput (relative to existing large-scale computing designs). Giving greater priority to both throughput-rate and cost considerations increases the relevance of primary memory performance and design optimisations to overall system performance. Using several primary memory performance benchmarks to evaluate various aspects of RAM and cache performance, we provide characterisations of the performances of four different models of ARM-based system-on-chip, namely the Cortex-A9, Cortex- A7, Cortex-A15 r3p2 and Cortex-A15 r3p3. We then discuss the relevance of these results to high volume computing and the potential for ARM processors.

The review of the distributed computing infrastructure of the Tier-1 sites for the Alice, ATLAS, LHCb experiments at the LHC is given. The special emphasis is placed on the main tasks and services of the Tier-1 site, which operates in the Kurchatov Institute in Moscow.

Nowadays cloud computing is an important topic in the field of information technology and computer system. Several companies and educational institutes have deployed cloud infrastructures to overcome their problems such as easy data access, software updates with minimal cost, large or unlimited storage, efficient cost factor, backup storage and disaster recovery, and some other benefits if compare with the traditional network infrastructures. The paper present the study of cloud computing technology for marine environmental data and processing. Cloud computing of marine environment information is proposed for the integration and sharing of marine information resources. It is highly desirable to perform empirical requiring numerous interactions with web servers and transfers of very large archival data files without affecting operational information system infrastructure. In this paper, we consider the cloud computing for virtual testbed to minimize the cost. That is related to real time infrastructure.