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We discuss key problems of self-organization theory, synergetics, and the prospects of its development for the next decades. We show that the future of this interdisciplinary approach probably is defined by the development of new network paradigm. We consider statements of several fundamental scientific and principle technological problems and concrete results giving rise to these conclusions.

Fluorescent imaging data are currently widely used in neuroscience and other fields. Genetically encoded sensors, based on fluorescent proteins, provide a wide inventory enabling scientiests to image virtually any process in a living cell and extracellular environment. However, especially due to the need for fast scanning, miniaturization, etc, the imaging data can be severly corrupred with multiplicative heteroscedactic noise, reflecting stochastic nature of photon emission and photomultiplier detectors. Deep learning architectures demonstrate outstanding performance in image segmentation and denoising, however they can require large clean datasets for training, and the actual data transformation is not evident from the network architecture and weight composition. On the other hand, some classical data transforms can provide for similar performance in combination with more clear insight in why and how it works. Here we propose an algorithm for denoising fluorescent dynamical imaging data, which is based on multilinear higher-order singular value decomposition (HOSVD) with optional truncation in rank along each axis and thresholding of the tensor of decomposition coefficients. In parallel, we propose a convenient paradigm for validation of the algorithm performance, based on simulated flurescent data, resulting from biophysical modeling of calcium dynamics in spatially resolved realistic 3D astrocyte templates. This paradigm is convenient in that it allows to vary noise level and its resemblance of the Gaussian noise and that it provides ground truth fluorescent signal that can be used to validate denoising algorithms. The proposed denoising method employs truncated HOSVD twice: first, narrow 3D patches, spanning the whole recording, are processed (local 3D-HOSVD stage), second, 4D groups of 3D patches are collaboratively processed (non-local, 4D-HOSVD stage). The effect of the first pass is twofold: first, a significant part of noise is removed at this stage, second, noise distribution is transformed to be more Gaussian-like due to linear combination of multiple samples in the singular vectors. The effect of the second stage is to further improve SNR. We perform parameter tuning of the second stage to find optimal parameter combination for denoising.

Explainable Artificial Intelligence (XAI) is a field of artificial intelligence aimed at creating methods and tools for generating interpretable and human-understandable explanations of AI decisions. The relevance of model explainability increases with the deployment of artificial intelligence in critical domains (healthcare, finance, law), where algorithmic opacity can lead to serious consequences for users and society. This work presents an analytical review of the current state of the XAI field, covering theoretical foundations, methodology, and practical applications.

The examined explainable AI methods were selected and systematized based on a multi-level classification of XAI methods by problem formulation (goal, target audience, data type), methodology (application stage, model-specificity, methods, scale), and result form (representation, presentation, evaluation metrics).

A comparative analysis of explainable AI methods for various application domains is conducted. For classical machine learning, SHAP and LIME are examined in detail, revealing their theoretical foundations, computational characteristics, and limitations. For computer vision, gradient-based methods (SmoothGrad, Integrated Gradients), activation visualization methods (Grad-CAM, Grad-CAM++), perturbation-based methods (RISE, Occlusion), and conceptual explanations (TCAV, Network Dissection) are systematized. Special attention is paid to the specifics of applying XAI to natural language processing and large language models, including analysis of the faithfulness of Chain-of-Thought reasoning, natural language explanations, and attribution graph methods. Fundamental limitations of existing approaches to LLM explainability are identified and directions for future research are defined.

The review results demonstrate that XAI methods have reached significant maturity in classical machine learning and computer vision, however, their application to large language models remains an open research problem requiring the development of new explanation paradigms.

The present article describes the authors’ model of construction of the distributed computer network and realization in it of the distributed calculations which are carried out within the limits of the software-information environment providing management of the information, automated and engineering systems of intellectual buildings. The presented model is based on the functional approach with encapsulation of the non-determined calculations and various side effects in monadic calculations that allows to apply all advantages of functional programming to a choice and execution of scenarios of management of various aspects of life activity of buildings and constructions. Besides, the described model can be used together with process of intellectualization of technical and sociotechnical systems for increase of level of independence of decision-making on management of values of parameters of the internal environment of a building, and also for realization of methods of adaptive management, in particular application of various techniques and approaches of an artificial intellect. An important part of the model is a directed acyclic graph, which is an extension of the blockchain with the ability to categorically reduce the cost of transactions taking into account the execution of smart contracts. According to the authors it will allow one to realize new technologies and methods — the distributed register on the basis of the directed acyclic graph, calculation on edge and the hybrid scheme of construction of artificial intellectual systems — and all this together can be used for increase of efficiency of management of intellectual buildings. Actuality of the presented model is based on necessity and importance of translation of processes of management of life cycle of buildings and constructions in paradigm of Industry 4.0 and application for management of methods of an artificial intellect with universal introduction of independent artificial cognitive agents. Model novelty follows from cumulative consideration of the distributed calculations within the limits of the functional approach and hybrid paradigm of construction of artificial intellectual agents for management of intellectual buildings. The work is theoretical. The article will be interesting to scientists and engineers working in the field of automation of technological and industrial processes both within the limits of intellectual buildings, and concerning management of complex technical and social and technical systems as a whole.