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Numerous contemporary studies confirm that neurons, astrocytes and blood vessels function as a unified dynamic system. Consequently, the concept of the integrated neurogliovascular unit (NGVU), encompassing these components, has emerged and gained significant traction in recent years. According to this framework, normal brain function relies on a broad complex of interactions between NGVU elements, while the disruption of these links may underlie various neuropathologies. Understanding the processes within a single NGVU, as well as the organization of connections between multiple units, is a prerequisite for successful diagnosis and therapy of neurological disorders.

In this work, we developed an NGVU model that, for the first time, integrates a detailed description of synaptically coupled excitatory and inhibitory neuronal networks (accounting for the E/I balance), extracellular environment dynamics (potassium, glutamate, GABA), and norepinephrine-modulated astrocytic activity, with subsequent regulation of local blood flow.

A key conceptual feature of the model is the integration of multiscale processes — ranging from ion dynamics at the level of individual Hodgkin – Huxley neurons to substance diffusion across a network of 100 NGVUs — into a single system of coupled nonlinear differential equations. This approach enabled the investigation of the ensemble’s collective dynamics and the identification of novel functional regimes.

Numerical experiments established that extracellular potassium dynamics and positive feedback play a decisive role in the formation of stable spatial excitation structures. It is shown that under local stimulation, activity remains confined due to potassium diffusion outflow; however, supercritical excitation initiates self-sustaining autowave regimes. The stabilization of these regimes leads to the formation of spatial patterns morphologically similar to Turing structures. These patterns, characterized by alternating zones of high and low activity, are independent of specific initial conditions but sensitive to parameter variations. This suggests that the system operates in a dynamic instability (chaos) regime, which is consistent with the concept of self-organized criticality of the brain under physiological conditions. The model successfully reproduces experimentally observed phenomena, including bursting and sensitivity to extracellular potassium. The results provide new perspectives for analyzing the pathophysiological mechanisms of brain function.

The paper addresses the problem of modeling the formation and propagation of panic states in social groups with relatively stable structures of interpersonal interactions. Panic is interpreted as a nonlinear process of emotional contagion arising from the interaction between individual psychological characteristics and collective effects within a social environment. In contrast to models focused on the spatial dynamics of moving crowds, the proposed approach concentrates on quasi-stationary interaction networks that reflect informational and emotional contacts among individuals.

The developed discrete network dynamical system integrates individual temperament parameters (sanguine, choleric, phlegmatic, melancholic), the structure of social connections, and nonlinear mechanisms of collective behavior. The individual dynamics of panic are described using an S-shaped growth function, which ensures boundedness of the emotional arousal level and captures the stages of its formation and saturation. Social influence is modeled on a graph of interpersonal interactions (an Erdos –Renyi random network) through local contacts between individuals.

Additionally, the model incorporates the effects of collective contagion and avalanche-like amplification driven by the average panic level in the group, as well as a baseline stress factor depending on group size. Numerical simulation is implemented in a discrete iterative form, allowing for the analysis of both individual and group panic trajectories. A quantitative indicator of the panic propagation rate is introduced, defined by the time required for the group to reach a state close to full panic.

A comparative analysis of heterogeneous and homogeneous groups is conducted, demonstrating that group heterogeneity significantly accelerates panic propagation due to inter-temperament interactions: highly excitable individuals act as initiators of emotional contagion, while more stable individuals partially dampen its dynamics. The evaluation of the model quality using the coefficient of determination shows a high degree of consistency within the simulation data.

The practical significance of the work lies in the potential application of the model for analyzing the resilience of social groups to panic states, assessing risks at mass events, and developing intelligent systems for monitoring collective behavior. Future research directions include extending the model to account for directed and dynamic networks, as well as its calibration based on empirical data.

The paper considers the basic model of competitive interactions and its use for the analysis and description of social processes. The peculiarity of the model is that it describes the interaction of several competing actors, while actors can vary the strategy of their actions, in particular, form coalitions to jointly counter a common enemy. As a result of modeling, various modes of competitive interaction were identified, their classification was conducted, and their features were described. In the course of the study, the attention is paid to the so-called “rough” (according to A.A. Andronov) cases of the implementation of competitive interaction, which until now have rarely been considered in the scientific literature, but are quite common in real life. Using a basic mathematical model, the conditions for the implementation of various modes of competitive interactions are considered, the conditions for the transition from one mode to another are determined, examples of the implementation of these modes in the economy, social and political life are given. It is shown that with a relatively low level of competition, which is non-antagonistic in nature, competition can lead to an increase in the activity of interacting actors and to overall economic growth. Moreover, in the presence of expanding resource opportunities (as long as such opportunities remain), this growth may have a hyperbolic character. With a decrease in resource capabilities and increased competition, there is a transition to an oscillatory mode, when weaker actors unite to jointly counteract stronger ones. With a further decrease in resource opportunities and increased competition, there is a transition to the formation of stable hierarchical structures. At the same time, the model shows that at a certain moment there is a loss of stability, the system becomes “rough” according to A.A. Andronov and sensitive to fluctuations in parameter changes. As a result, the existing hierarchies may collapse and be replaced by new ones. With a further increase in the intensity of competition, the actor-leader completely suppresses his opponents and establishes monopolism. Examples from economic, social, and political life are given, illustrating the patterns identified on the basis of modeling using the basic model of competition. The obtained results can be used in the analysis, modeling and forecasting of socioeconomic and political processes.

Studies of the crisis socio-demographic situation in the Russian Far East require not only the use of traditional statistical methods, but also a conceptual analysis of possible development scenarios based on the synergy principles. The article is devoted to the analysis and modeling of the number of employed, unemployed and economically inactive population using nonlinear autonomous differential equations. We studied a basic mathematical model that takes into account the principle of pair interactions, which is a special case of the model for the struggle between conditional information of D. S. Chernavsky. The point estimates for the parameters are found using least squares method adapted for this model. The average approximation error was no more than 5.17%. The calculated parameter values correspond to the unstable focus and the oscillations with increasing amplitude of population number in the asymptotic case, which indicates a gradual increase in disparities between the employed, unemployed and economically inactive population and a collapse of their dynamics. We found that in the parametric space, not far from the inertial scenario, there are domains of blow-up and chaotic regimes complicating the ability to effectively manage. The numerical study showed that a change in only one model parameter (e.g. migration) without complex structural socio-economic changes can only delay the collapse of the dynamics in the long term or leads to the emergence of unpredictable chaotic regimes. We found an additional set of the model parameters corresponding to sustainable dynamics (stable focus) which approximates well the time series of the considered population groups. In the mathematical model, the bifurcation parameters are the outflow rate of the able-bodied population, the fertility (“rejuvenation of the population”), as well as the migration inflow rate of the unemployed. We found that the transition to stable regimes is possible with the simultaneous impact on several parameters which requires a comprehensive set of measures to consolidate the population in the Russian Far East and increase the level of income in terms of compensation for infrastructure sparseness. Further economic and sociological research is required to develop specific state policy measures.

The purpose of this study is to develop a methodology for change points detection in time series, including financial data. The theoretical basis of the study is based on the pieces of research devoted to the analysis of structural changes in financial markets, description of the proposed algorithms for detecting change points and peculiarities of building classical and deep machine learning models for solving this type of problems. The development of such tools is of interest to investors and other stakeholders, providing them with additional approaches to the effective analysis of financial markets and interpretation of available data.

To address the research objective, a neural network was trained. In the course of the study several ways of training sample formation were considered, differing in the nature of statistical parameters. In order to improve the quality of training and obtain more accurate results, a methodology for feature generation was developed for the formation of features that serve as input data for the neural network. These features, in turn, were derived from an analysis of mathematical expectations and standard deviations of time series data over specific intervals. The potential for combining these features to achieve more stable results is also under investigation.

The results of model experiments were analyzed to compare the effectiveness of the proposed model with other existing changepoint detection algorithms that have gained widespread usage in practical applications. A specially generated dataset, developed using proprietary methods, was utilized as both training and testing data. Furthermore, the model, trained on various features, was tested on daily data from the S&P 500 index to assess its effectiveness in a real financial context.

As the principles of the model’s operation are described, possibilities for its further improvement are considered, including the modernization of the proposed model’s structure, optimization of training data generation, and feature formation. Additionally, the authors are tasked with advancing existing concepts for real-time changepoint detection.