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Location-based models — one of areas of CAMA (computer-assisted mass apriasal) building. When taking into account the location of the object using spatial autoregressive models structure of models (type of spatial autocorrelation, choice of “nearest neighbors”) cannot always be determined before its construction. Moreover, in practice there are situations where more efficient methods are taking into account different rates depending on the type of the object from its location. In this regard there are important issues in spatial methods area:

– fields of methods efficacy;

– sensitivity of the methods on the choice of the type of spatial model and on the selected number of nearest neighbors.

This article presents a methodology for assessing the effectiveness of computer evaluation of real estate objects. There are results of approbation on methods based on location information of the objects.

Modern mathematical models in the dynamics system “soil–plant” are considered. The components of this system are: agricultural plant, microorganisms of the rhizosphere (root zone of plants), the mineral nutrition elements of plants in their mobile and immobile forms. The model of submitted system based on the analysis of the adopted provisions was developed. The construction of system elements allows to display the coordinated dynamics of these elements among themselves. In particular, the dynamics of mineral nutrition elements in plants and the dynamics of their biomass are determined by the current contents in the rhizosphere of mineral fertilizers and organic origin substances (plant roots, leaves, etc.). The immobility of plants spatial distribution and the mobile spatial nature of microorganisms are assumed. This mechanism is determined by diffusion. Mutual relationships between weeds and pests are suggested. The dynamics of the mineral nutrition elements is determined by the peculiarity of sorption in the soil solution, environmental conditions, organic decomposition and fertilizer application. An analytical study for a system where each of the components is represented by only one species (fertilizer, the association of microorganisms and plants) was performed. An adaptation of the wave propagation model in the “resource–consumer” system (Kolmogorov–Petrovsky–Piskunov waves) has been developed for annual agricultural crops. The developed model has been adapted for the growth of Krasnoufimskaya-100 spring wheat in a vessel on peat lowland soil, where nitrogen, phosphorus, and potassium fertilizers were added variably. Sample distributions are plants biomass and the content of mineral nutrition elements in them. The parametric identification of the model and its adequacy was performed. An assessment of the model adequacy showed a good agreement between the model and experimental data.

The paper provides a comparative analysis of the results obtained by various approaches to modeling the process of artillery shot. In this connection, the main problem of internal ballistics and its particular case of the Lagrange problem are formulated in averaged parameters, where, within the framework of the assumptions of the thermodynamic approach, the distribution of pressure and gas velocity over the projectile space for a channel of variable cross section is taken into account for the first time. The statement of the Lagrange problem is also presented in the framework of the gas-dynamic approach, taking into account the spatial (one-dimensional and two-dimensional axisymmetric) changes in the characteristics of the ballistic process. The control volume method is used to numerically solve the system of Euler gas-dynamic equations. Gas parameters at the boundaries of control volumes are determined using a selfsimilar solution to the Riemann problem. Based on the Godunov method, a modification of the Osher scheme is proposed, which allows to implement a numerical calculation algorithm with a second order of accuracy in coordinate and time. The solutions obtained in the framework of the thermodynamic and gas-dynamic approaches are compared for various loading parameters. The effect of projectile mass and chamber broadening on the distribution of the ballistic parameters of the shot and the dynamics of the projectile motion was studied. It is shown that the thermodynamic approach, in comparison with the gas-dynamic approach, leads to a systematic overestimation of the estimated muzzle velocity of the projectile in the entire range of parameters studied, while the difference in muzzle velocity can reach 35%. At the same time, the discrepancy between the results obtained in the framework of one-dimensional and two-dimensional gas-dynamic models of the shot in the same range of change in parameters is not more than 1.3%.

A spatial gas-dynamic formulation of the backpressure problem is given, which describes the change in pressure in front of an accelerating projectile as it moves along the barrel channel. It is shown that accounting the projectile’s front, considered in the two-dimensional axisymmetric formulation of the problem, leads to a significant difference in the pressure fields behind the front of the shock wave, compared with the solution in the framework of the onedimensional formulation of the problem, where the projectile’s front is not possible to account. It is concluded that this can significantly affect the results of modeling ballistics of a shot at high shooting velocities.

The spatiotemporal dynamics of a three-component model for food web is considered. The model describes the interactions among resource, prey and predator that consumes both species. In a previous work, the author analyzed the model without taking into account spatial heterogeneity. This study continues the model study of the community considering the diffusion of individuals, as well as directed movements of the predator. It is assumed that the predator responds to the spatial change in the resource and prey density by occupying areas where species density is higher or avoiding them. Directed predator movement is described by the advection term, where velocity is proportional to the gradient of resource and prey density. The system is considered on a one-dimensional domain with zero-flux conditions as boundary ones. The spatiotemporal dynamics produced by model is determined by the system stability in the vicinity of stationary homogeneous state with respect to small inhomogeneous perturbations. The paper analyzes the possibility of wave instability leading to the emergence of autowaves and Turing instability, as a result of which stationary patterns are formed. Sufficient conditions for the existence of both types of instability are obtained. The influence of local kinetic parameters on the spatial structure formation was analyzed. It was shown that only Turing instability is possible when taxis on the resource is positive, but with a negative taxis, both types of instability are possible. The numerical solution of the system was found by using method of lines (MOL) with the numerical integration of ODE system by means of splitting techniques. The spatiotemporal dynamics of the system is presented in several variants, realizing one of the instability types. In the case of a positive taxis on the prey, both autowave and stationary structures are formed in smaller regions, with an increase in the region size, Turing structures are not formed. For negative taxis on the prey, stationary patterns is observed in both regions, while periodic structures appear only in larger areas.

The work solves the problem of establishing the dependence of the potential for spatial selection of useful and interfering signals according to the signal-to-interference ratio criterion on the positioning error of user equipment during beamforming by their location at a base station, equipped with an antenna array. Configurable simulation parameters include planar antenna array with a different number of antenna elements, movement trajectory, as well as the accuracy of user equipment location estimation using root mean square error of coordinate estimates. The model implements three algorithms for controlling the shape of the antenna radiation pattern: 1) controlling the beam direction for one maximum and one zero; 2) controlling the shape and width of the main beam; 3) adaptive beamforming. The simulation results showed, that the first algorithm is most effective, when the number of antenna array elements is no more than 5 and the positioning error is no more than 7 m, and the second algorithm is appropriate to employ, when the number of antenna array elements is more than 15 and the positioning error is more than 5 m. Adaptive beamforming is implemented using a training signal and provides optimal spatial selection of useful and interfering signals without device location data, but is characterized by high complexity of hardware implementation. Scripts of the developed models are available for verification. The results obtained can be used in the development of scientifically based recommendations for beam control in ultra-dense millimeter-wave radio access networks of the fifth and subsequent generations.

Despite the widespread use of cancer chemotherapy drugs, the molecular mechanisms of action of many of them remain unclear. Some of these drugs, such as taxol, are known to affect the dynamics of microtubule assembly and stop the process of cell division in prophase-prometaphase. Recently, new spatial structures of microtubules and individual tubulin oligomers have emerged associated with various regulatory proteins and cancer chemotherapy drugs. However, knowledge of the spatial structure in itself does not provide information about the mechanism of action of drugs.

In this work, we applied the molecular dynamics method to study the behavior of taxol-bound tubulin oligomers and used our previously developed method for analyzing the conformation of tubulin protofilaments, based on the calculation of modified Euler angles. Recent structures of microtubule fragments have demonstrated that tubulin protofilaments bend not in the radial direction, as many researchers assume, but at an angle of approximately 45◦ from the radial direction. However, in the presence of taxol, the bending direction shifts closer to the radial direction. There was no significant difference between the mean bending and torsion angles of the studied tubulin structures when bound to the various natural regulatory ligands, guanosine triphosphate and guanosine diphosphate. The intra-dimer bending angle was found to be greater than the interdimer bending angle in all analyzed trajectories. This indicates that the bulk of the deformation energy is stored within the dimeric tubulin subunits and not between them. Analysis of the structures of the latest generation of tubulins indicated that the presence of taxol in the tubulin beta subunit pocket allosterically reduces the torsional rigidity of the tubulin oligomer, which could explain the underlying mechanism of taxol’s effect on microtubule dynamics. Indeed, a decrease in torsional rigidity makes it possible to maintain lateral connections between protofilaments, and therefore should lead to the stabilization of microtubules, which is what is observed in experiments. The results of the work shed light on the phenomenon of dynamic instability of microtubules and allow to come closer to understanding the molecular mechanisms of cell division.

The author has analyzed main approaches to the mass appraisal of real property (Russian and foreign), pros and cons are pointed out. An approach based on spatial regression models which shows results better than conventional regression models and applicable to Russian real estate market is presented in the article.

The grid-characteristic method is successfully used for solving hyperbolic systems of partial differential equations (for example, transport / acoustic / elastic equations). It allows to construct correctly algorithms on contact boundaries and boundaries of the integration domain, to a certain extent to take into account the physics of the problem (propagation of discontinuities along characteristic curves), and has the property of monotonicity, which is important for considered problems. In the cases of two-dimensional and three-dimensional problems the method makes use of a coordinate splitting technique, which enables us to solve the original equations by solving several one-dimensional ones consecutively. It is common to use up to 3-rd order one-dimensional schemes with simple splitting techniques which do not allow for the convergence order to be higher than two (with respect to time). Significant achievements in the operator splitting theory were done, the existence of higher-order schemes was proved. Its peculiarity is the need to perform a step in the opposite direction in time, which gives rise to difficulties, for example, for parabolic problems.

In this work coordinate splitting of the 3-rd and 4-th order were used for the two-dimensional hyperbolic problem of the linear elasticity. This made it possible to increase the final convergence order of the computational algorithm. The paper empirically estimates the convergence in L1 and L∞ norms using analytical solutions of the system with the sufficient degree of smoothness. To obtain objective results, we considered the cases of longitudinal and transverse plane waves propagating both along the diagonal of the computational cell and not along it. Numerical experiments demonstrated the improved accuracy and convergence order of constructed schemes. These improvements are achieved with the cost of three- or fourfold increase of the computational time (for the 3-rd and 4-th order respectively) and no additional memory requirements. The proposed improvement of the computational algorithm preserves the simplicity of its parallel implementation based on the spatial decomposition of the computational grid.

The article proposes a space-time approach to modeling the diffusion of information and communication technologies based on the Fisher –Kolmogorov– Petrovsky – Piskunov equation, in which the diffusion kinetics is described by the Bass model, which is widely used to model the diffusion of innovations in the market. For this equation, its equilibrium positions are studied, and based on the singular perturbation theory, was obtained an approximate solution in the form of a traveling wave, i. e. a solution that propagates at a constant speed while maintaining its shape in space. The wave speed shows how much the “spatial” characteristic, which determines the given level of technology dissemination, changes in a single time interval. This speed is significantly higher than the speed at which propagation occurs due to diffusion. By constructing such an autowave solution, it becomes possible to estimate the time required for the subject of research to achieve the current indicator of the leader.

The obtained approximate solution was further applied to assess the factors affecting the rate of dissemination of information and communication technologies in the federal districts of the Russian Federation. Various socio-economic indicators were considered as “spatial” variables for the diffusion of mobile communications among the population. Growth poles in which innovation occurs are usually characterized by the highest values of “spatial” variables. For Russia, Moscow is such a growth pole; therefore, indicators of federal districts related to Moscow’s indicators were considered as factor indicators. The best approximation to the initial data was obtained for the ratio of the share of R&D costs in GRP to the indicator of Moscow, average for the period 2000–2009. It was found that for the Ural Federal District at the initial stage of the spread of mobile communications, the lag behind the capital was less than one year, for the Central Federal District, the Northwestern Federal District — 1.4 years, for the Volga Federal District, the Siberian Federal District, the Southern Federal District and the Far Eastern Federal District — less than two years, in the North Caucasian Federal District — a little more 2 years. In addition, estimates of the delay time for the spread of digital technologies (intranet, extranet, etc.) used by organizations of the federal districts of the Russian Federation from Moscow indicators were obtained.

The results of homology modeling of HydSL, a NiFe-hydrogenase from purple sulphur bacterium Thiocapsa roseopersicina BBS are presented in this work. It is shown that the models have larger confidence level than earlier published ones; a full-size model of HydSL hydrogenase is presented for the first time. The C-end fragment of the enzyme is shown to have random orientation in relation to the main protein globule. The obtain models have a large number of ion pairs, as well as thermostable HydSL hydrogenase from Allochromatium vinosum, in contrast to thermolabile HydAB hydrogenase from Desulfovibrio vulgaris.