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The effectiveness of communication and data transmission systems (CSiPS), which are an integral part of modern systems in almost any field of science and technology, largely depends on the stability of the frequency of the generated signals. The signals generated in the CSiPD can be considered as processes, the frequency of which changes under the influence of a combination of external influences. Changing the frequency of the signals leads to a decrease in the signal-tonoise ratio (SNR) and, consequently, a deterioration in the characteristics of the signal-to-noise ratio, such as the probability of a bit error and bandwidth. It is most convenient to consider the description of such changes in the frequency of signals as random processes, the apparatus of which is widely used in the construction of mathematical models describing the functioning of systems and devices in various fields of science and technology. Moreover, in many cases, the characteristics of a random process, such as the distribution law, mathematical expectation, and variance, may be unknown or known with errors that do not allow us to obtain estimates of the signal parameters that are acceptable in accuracy. The article proposes an algorithm for solving the problem of determining the characteristics of a random process (signal frequency) based on a set of samples of its frequency, allowing to determine the sample mean, sample variance and the distribution law of frequency deviations in the general population. The basis of this algorithm is the comparison of the values of the observed random process measured over a certain time interval with a set of the same number of random values formed on the basis of model distribution laws. Distribution laws based on mathematical models of these systems and devices or corresponding to similar systems and devices can be considered as model distribution laws. When forming a set of random values for the accepted model distribution law, the sample mean value and variance obtained from the measurement results of the observed random process are used as mathematical expectation and variance. The feature of the algorithm is to compare the measured values of the observed random process ordered in ascending or descending order and the generated sets of values in accordance with the accepted models of distribution laws. The results of mathematical modeling illustrating the application of this algorithm are presented.

In molecular systems with hydrogen bonds the mechanism of proton relaxation can take place. It is caused by redistribution of protons between two steady positions in double walls potential along the line of the hydrogen bond. This redistribution occurs at change of parameters of the double walls potential of the hydrogen bond which is caused by change of an electronic state of molecular system. The relaxation process is carried out due to a tunnel transfer of protons along the line of bonds. It is shown, that relaxation process can define temperature dependence of power parameters (either of the free energy differences ΔG or of the reorganization energy λ) of charge recombination P⁺Q^-_A from RC of Rhodobacter sphaeroides.

Mathematical model of infiltrative tumour growth taking into account transitions between two possible states of malignant cell is investigated. These transitions are considered to depend on oxygen level in a threshold manner: high oxygen concentration allows cell proliferation, while concentration below some critical value induces cell migration. Dependence of infiltrative tumour spreading rate on model parameters has been studied. It is demonstrated that if the level of tissue oxygenation is high, tumour spreading rate remains almost constant; otherwise the spreading rate decreases dramatically with oxygen depletion.

An approach to evaluation of a parametric portrait of integral equations of the theory of liquids in the RISM approximation was proposed. To obtain all associated solutions the continuation method was used. The equations reduced to a two-centered molecule model for symmetry reasons were deduced for molecular liquids. For molecular liquids, some equations were obtained which could be reduced, for symmetry reasons, to a two-center molecular model. To avoid critical points we changed the dependence of RISM-equations on reverse compressibility. The suggested method was used to perform numerical computations of methane reverse compressibility isotherms with three closures. No bifurcation of solutions was observed in the case of the partially linearized hypernetted chain closure. For other closures bifurcations of solutions were obtained and the model behavior nontypical for simple liquids was observed. In the case of Percus-Yevick closure nonphysical solutions were obtained at low temperature and density. Additional solution branch with a kink in the bifurcation point was obtained in the case of hypernetted chain closure at temperature above the critical point.

This study analyzes the abundance of mononucleotide tracts of different length in 342 eubacterial and 69 archaeal chromosomes. Despite the fact that the amount of analyzed repeats depends on nucleotide content, the predominance of poly(dA)_n- and poly(dT)_n-tracts on poly(dG)_n- and poly(dC)_n-tracts was found in 301 chromosomes (73 % of events), including 90 GC-rich chromosomes. In natural DNAs amount of A/T-tracts usually appeared to be two-fold higher than in randomized nucleotide sequences with the same AT/GC-content and length. Possible reasons of this asymmetry in distribution are discussed.

The computer code NINE (Newtonian Iteration for Nonlinear Equation) for numerical solution of the boundary problems for nonlinear differential equations on the basis of continuous analogue of the Newton method (CANM) is presented. Numerov’s finite-difference appproximation is applied to provide the fourth accuracy order with respect to the discretization stepsize. Algorithms of calculating the Newtonian iterative parameter are discussed. A convergence of iteration process in dependence on choice of the iteration parameter has been studied. Results of numerical investigation of the particle-like solutions of the scalar field equation are given.

Molecular dynamics (MD) simulations of rigid water model TIP4P-EW at ambient conditions were carried out. Delaunay’s simplexes were considered as structural elements of liquid water. Topological criterion which allows to identify the water microstructure in snapshot of MD cell was used to allocate its dense part. Geometrical analysis of water Delaunay’s simplexes indicates their strong flatness in comparison with a regular tetrahedron that is fundamentally different from the results for dense part of simple liquids. The statistics of TIP4P-EW water clusters was investigated depending on their cardinality and connectivity. It is similar to the statistics for simple liquids and the structure of this dense part is also a fractal surface consisting of the free edges of the Delaunay’s simplexes.

The problem is formulated for description of objects having various natures which uses a system of linear equations with variable number exceeding the number of the equations. An important feature of this problem that substantially complicates its solving is the existing of restrictions imposed on a number of the variables. In particular, the choice of biochemical reaction aggregate that converts a preset substrate (a feedstock) into a preset product belongs to this kind of problems. In this case, unknown variables are the rates of biochemical reactions which form a vector to be determined. Components of this vector are subdivided into two groups: 1) the defined components, $\vec{y}$; 2) those dependent on the defined ones, $\vec{x}$. Possible configurations of the domain of $\vec{y}$ values permitted by restrictions imposed upon $\vec{x}$ components have been studied. It has been found that a part of restrictions may be superfluous and, therefore, unnecessary for the problem solving. Situations are analyzed when two or more $\vec{x}$ restrictions result in strict interconnections between $\vec{y}$ components. Methods of search of the basis solutions which take into account the peculiarities of this problem are described. Statement of the general problem and properties of its solutions are illustrated using a biochemical example.

Numerical analysis of the effects of the local heat source shape on transient natural convection in a square enclosure has been carried out. The local heat source has rectangular, triangular and trapezoidal shape. The boundary value problem formulated in the dimensionless variables such as stream function, vorticity and temperature by using the Boussinesq approximation has been solved by means of finite difference method. Distributions of streamlines and isotherms and time dependences for the average Nusselt number along the heat source surface in a wide range of governing parameters have been obtained.

In this paper on the basis of the riverbed model proposed earlier the one-dimensional stability problem of closed flow channel with sandy bed is solved. The feature of the investigated problem is used original equation of riverbed deformations, which takes into account the influence of mechanical and granulometric bed material characteristics and the bed slope when riverbed analyzing. Another feature of the discussed problem is the consideration together with shear stress influence normal stress influence when investigating the riverbed instability. The analytical dependence determined the wave length of fast-growing bed perturbations is obtained from the solution of the sandy bed stability problem for closed flow channel. The analysis of the obtained analytical dependence is performed. It is shown that the obtained dependence generalizes the row of well-known empirical formulas: Coleman, Shulyak and Bagnold. The structure of the obtained analytical dependence denotes the existence of two hydrodynamic regimes characterized by the Froude number, at which the bed perturbations growth can strongly or weakly depend on the Froude number. Considering a natural stochasticity of the waves movement process and the presence of a definition domain of the solution with a weak dependence on the Froude numbers it can be concluded that the experimental observation of the of the bed waves movement development should lead to the data acquisition with a significant dispersion and it occurs in reality.